HIST2H4A and NAP1L4

Number of citations of the paper that reports this interaction (PMID 9325046)
23

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		HIST2H4A	NAP1L4
Gene Name		histone cluster 2, H4a	nucleosome assembly protein 1-like 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Nucleosome Assembly
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		27 interactors: ATAD2 BRD4 BRDT DNMT3L EP300 HAT1 HIST1H3A HIST2H2AC KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UBC UCHL5 UHRF1 YWHAQ	10 interactors: CSNK2A1 CSNK2A2 EP300 HIST1H1A HIST1H2AE HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3
Entrez ID		8370	4676
HPRD ID		11821	11873
Ensembl ID		ENSG00000183941	ENSG00000205531
Uniprot IDs		B2R4R0 P62805	F5HFY4 Q99733
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Nucleosome Organization Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cellular Metabolic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Assembly Histone H4 Acetylation Peptidyl-lysine Modification DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Positive Regulation Of Metabolic Process	DNA Methylation On Cytosine Nucleosome Assembly Chromatin Silencing At RDNA Chromatin Assembly Nucleosome Organization Chromosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Silencing Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Chromatin Organization Mitotic Cell Cycle DNA Conformation Change Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition DNA Methylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression, Epigenetic Histone H2B Acetylation Negative Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Negative Regulation Of Cell Division Regulation Of Chromosome Segregation DNA Modification Negative Regulation Of Chromosome Organization Gene Silencing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division N-terminal Peptidyl-lysine Acetylation Histone H4-K20 Demethylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cellular Macromolecular Complex Assembly Negative Regulation Of Megakaryocyte Differentiation Regulation Of Tubulin Deacetylation Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?			11p15 approved cloning competition cooh deduced demonstrates etiology g401 hgmw histones intron linker mutagenesis mutational naked nh3 nucleosome onto packaging positional shuttle subcellular symbol templates wilms wt wts
Tagcloud (Difference) ?			11p15 approved cloning competition cooh deduced demonstrates etiology g401 hgmw histones intron linker mutagenesis mutational naked nh3 nucleosome onto packaging positional shuttle subcellular symbol templates wilms wt wts
Tagcloud (Intersection) ?