HIST2H4A and RAD51B

Number of citations of the paper that reports this interaction (PMID 14595808)
4

Data Source:
HPRD (in vitro)

		HIST2H4A	RAD51B
Gene Name		histone cluster 2, H4a	RAD51 paralog B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Reciprocal Meiotic Recombination Blood Coagulation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23455636) Breast cancer (male) ( 23001122) Prostate cancer ( 23535732)
Protein-Protein Interactions		27 interactors: ATAD2 BRD4 BRDT DNMT3L EP300 HAT1 HIST1H3A HIST2H2AC KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UBC UCHL5 UHRF1 YWHAQ	9 interactors: FAM9B H1F0 HIST1H2BG HIST1H3A HIST2H4A RAD51C RAD51D SWSAP1 UBC
Entrez ID		8370	5890
HPRD ID		11821	04255
Ensembl ID		ENSG00000183941	ENSG00000182185
Uniprot IDs		B2R4R0 P62805	O15315
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Nucleosome Organization Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cellular Metabolic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Assembly Histone H4 Acetylation Peptidyl-lysine Modification DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Positive Regulation Of Metabolic Process	DNA Metabolic Process Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromosome Organization DNA Packaging DNA Conformation Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Double-strand Break Repair DNA Repair Cellular Macromolecular Complex Assembly DNA Recombination Chromatin Organization Chromatin Silencing Nucleobase-containing Compound Metabolic Process Reciprocal Meiotic Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Methylation Response To Stress Protein Complex Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification DNA Catabolic Process, Endonucleolytic Gene Silencing Meiosis I Cell Cycle Female Meiosis Sister Chromatid Cohesion Strand Invasion DNA Catabolic Process Cellular Response To Stress Histone H4-K20 Demethylation Meiotic Nuclear Division Negative Regulation Of Megakaryocyte Differentiation Meiotic Sister Chromatid Cohesion Meiotic Cell Cycle Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Cellular Macromolecule Catabolic Process
Tagcloud ?			aetiology argues atlas billion clues coadaptation cohorts comprehensive confirms constitutes encompassing extends give insertions landscape map massively observe oncogene papillomavirus proved reads screen sequencing transcriptome tumour uncovering unprecedented viruses
Tagcloud (Difference) ?			aetiology argues atlas billion clues coadaptation cohorts comprehensive confirms constitutes encompassing extends give insertions landscape map massively observe oncogene papillomavirus proved reads screen sequencing transcriptome tumour uncovering unprecedented viruses
Tagcloud (Intersection) ?