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HIST2H4A and BRDT
Number of citations of the paper that reports this interaction (PMID
12861021
)
38
Data Source:
HPRD
(in vivo)
HIST2H4A
BRDT
Gene Name
histone cluster 2, H4a
bromodomain, testis-specific
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleus
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Transcription Coactivator Activity
Histone Binding
Lysine-acetylated Histone Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Histone Displacement
Chromatin Remodeling
Transcription, DNA-templated
MRNA Processing
Male Meiosis
Male Meiosis I
Spermatogenesis
RNA Splicing
Cell Differentiation
Regulation Of RNA Splicing
Positive Regulation Of Transcription During Meiosis
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
2 interactors:
HIST2H4A
VAV2
Entrez ID
8370
676
HPRD ID
11821
03684
Ensembl ID
ENSG00000183941
ENSG00000137948
Uniprot IDs
B2R4R0
P62805
Q58F21
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
2RFJ
4FLP
4KCX
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Histone H4-K20 Demethylation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
DNA Replication-dependent Nucleosome Assembly
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Regulation Of Megakaryocyte Differentiation
CENP-A Containing Nucleosome Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Regulation Of Hematopoietic Progenitor Cell Differentiation
Histone Exchange
Histone Lysine Demethylation
Chromatin Silencing
DNA Replication-independent Nucleosome Assembly
Histone Demethylation
Regulation Of Immune System Process
Protein Demethylation
Lamellipodium Assembly
Centromere Complex Assembly
Lamellipodium Organization
Regulation Of Phosphatidylinositol 3-kinase Activity
Regulation Of Lipid Kinase Activity
DNA Methylation
Demethylation
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Telomere Maintenance
Cellular Component Assembly
Negative Regulation Of Myeloid Cell Differentiation
DNA Modification
Ephrin Receptor Signaling Pathway
Regulation Of Blood Coagulation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Gene Silencing
Nucleosome Assembly
Tagcloud
?
academia
acetyllysine
bet
biotechnology
bona
brd2
brd3
brd4
bromodomain
chemotypes
claiming
companies
compelling
covered
covering
disclosing
expert
extra
fide
kac
opinion
outlined
patent
patents
pharmaceutical
readers
tails
underway
Tagcloud (Difference)
?
academia
acetyllysine
bet
biotechnology
bona
brd2
brd3
brd4
bromodomain
chemotypes
claiming
companies
compelling
covered
covering
disclosing
expert
extra
fide
kac
opinion
outlined
patent
patents
pharmaceutical
readers
tails
underway
Tagcloud (Intersection)
?