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HIST2H4A and SET
Number of citations of the paper that reports this interaction (PMID
11163245
)
114
Data Source:
HPRD
(in vitro, in vivo)
HIST2H4A
SET
Gene Name
histone cluster 2, H4a
SET nuclear proto-oncogene
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Protein Complex
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
DNA Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Histone Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Mitotic Cell Cycle
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Nucleocytoplasmic Transport
Gene Expression
Negative Regulation Of Histone Acetylation
Negative Regulation Of Catalytic Activity
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Catalytic Activity
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Regulation of mRNA stability by proteins that bind AU-rich elements
Mitotic Prophase
Condensation of Prophase Chromosomes
HuR stabilizes mRNA
Cell Cycle, Mitotic
M Phase
Drugs
Diseases
GWAS
Eating disorders (purging via substances) (
23568457
)
Protein-Protein Interactions
27 interactors:
ATAD2
BRD4
BRDT
DNMT3L
EP300
HAT1
HIST1H3A
HIST2H2AC
KAT2A
KAT5
LBR
NAP1L4
PRMT1
PTMA
RAD51B
RBBP4
RNF20
RPS6KA5
SET
TAF15
TBL1X
TBL1XR1
TP53BP1
UBC
UCHL5
UHRF1
YWHAQ
51 interactors:
ANP32A
APEX1
APP
CALM1
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
EP300
FAM111B
FOS
GZMA
GZMK
HDAC1
HIST1H2BA
HIST1H3A
HIST2H4A
HIST3H3
HIST4H4
HMGB2
IRF1
JUNB
KLF5
KMT2A
MDM2
MEOX2
MTERF1
NME1
NUCB1
NUPR1
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTMA
RAC1
SDCBP
SETBP1
SGOL1
TAF1A
TERF1
TERF2
TERF2IP
THAP7
TP53
TREX1
UCHL5
Entrez ID
8370
6418
HPRD ID
11821
09023
Ensembl ID
ENSG00000183941
ENSG00000119335
Uniprot IDs
B2R4R0
P62805
Q01105
Q5VXV3
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
2E50
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Organelle Organization
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Transcription, DNA-templated
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
RNA Biosynthetic Process
Protein Acetylation
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
DNA Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Positive Regulation Of Cellular Metabolic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Chromatin Assembly
Histone H4 Acetylation
Peptidyl-lysine Modification
DNA Methylation On Cytosine
Chromatin Assembly Or Disassembly
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Metabolic Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Chromosome Organization
Regulation Of Transcription, DNA-templated
Cell Death
Death
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
Telomere Maintenance
Developmental Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Apoptotic Process
Programmed Cell Death
Regulation Of Cell Cycle Process
Cellular Metabolic Process
DNA Replication-dependent Nucleosome Assembly
Cell Cycle
Transcription, DNA-templated
Organelle Organization
Regulation Of Gene Expression, Epigenetic
Blood Coagulation
Positive Regulation Of Protein Metabolic Process
Chromatin Assembly
RNA Biosynthetic Process
Cellular Component Assembly
Hemostasis
Chromatin Organization
Negative Regulation Of Cell Cycle
Anatomical Structure Development
Cellular Response To Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Body Fluid Levels
Negative Regulation Of Transcription, DNA-templated
Response To Growth Factor
Negative Regulation Of Gene Expression
Tagcloud
?
already
assessing
cognition
cognitive
cogs
computation
correlating
costs
cps
deterioration
easy
estimate
exam
global
inasmuch
mds
meaningful
mental
mini
minimum
msd
quite
residents
scale
scales
simple
slightly
straightforward
substantially
utility
Tagcloud (Difference)
?
already
assessing
cognition
cognitive
cogs
computation
correlating
costs
cps
deterioration
easy
estimate
exam
global
inasmuch
mds
meaningful
mental
mini
minimum
msd
quite
residents
scale
scales
simple
slightly
straightforward
substantially
utility
Tagcloud (Intersection)
?