HDAC2 and VHL

Number of citations of the paper that reports this interaction (PubMedID 22286234)
48

Data Source:
BioGRID (genetic interference, pull down, affinity chromatography technology)

		HDAC2	VHL
Description		histone deacetylase 2	von Hippel-Lindau tumor suppressor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Membrane
	Molecular Function	Transcription Coregulator Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Histone Binding Histone Deacetylase Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding	Transcription Elongation Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Molecular Adaptor Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Organization Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuron Projection Development Dendrite Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Caffeine Heterochromatin Formation Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Nicotine Protein Modification Process Response To Cocaine Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Progesterone Receptor Signaling Pathway Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Positive Regulation Of Male Mating Behavior Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine Response To Amyloid-beta Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Cellular Response To Hypoxia Regulation Of Cellular Response To Hypoxia Negative Regulation Of TORC1 Signaling Amyloid Fibril Formation
Pathways		p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases			von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT) Renal cell carcinoma
GWAS		Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)	Bullous pemphigoid ( 34011352) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		97 interacting genes: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CEBPA CHFR CIRSR CSNK2A1 CSNK2A2 CTBP1 CUL4B CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX IFRD1 IKZF1 IKZF4 ING1 JUP MAD1L1 MBD2 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TMEM132D TOP2A TOP2B TP53 UBC USP4 VHL YY1 ZBTB16 ZNF461	172 interacting genes: ACTB AHI1 AKT1 ANKEF1 ANKRD11 APP ARHGEF7 AURKA BEX2 BEX4 BRCA1 BRD4 CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CCT5 CCT7 CD44 CDC34 CDK1 CDK5RAP3 CDKN2A CERKL CHEK2 CLU COL4A2 COMMD1 CPNE5 CSNK2A1 CUL2 CUL5 DGKI DIDO1 DNAJA3 DSTN DVL2 E2F1 EEF1A1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR ERI1 ETFA FBXO28 FBXO34 FKBP8 FLNA FLOT1 FN1 GHET1 GPANK1 GPS1 GTF3C2 GUK1 H1-2 H2BC13 H4C16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IFT88 IKBKB ITPKC JADE1 KIF2C KIF3A KLF4 KLHL10 LANCL1 MAP1B MAP1LC3B MAP1S MDFI MRPS9 MSL2 MT-CO2 NCL NISCH NR4A1 NR4A2 NR4A3 NSUN5 NSUN7 OTUD6B PAX2 PDCD5 PFKP PHB2 PIAS4 PIWIL4 PKP2 PLD1 PLD2 POLR2G PPP1R13L PPP5C PRDX1 PRKCI PRKG1 PRMT1 PRMT8 PSMC1 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RERE RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SAP30 SARNP SAT2 SELENOP SETDB1 SKP2 SLC2A1 SLC3A2 SMC5 SNRNP200 SON SP1 SPARC SPATA22 SPZ1 STAMBP SUV39H2 TBK1 TDRD7 TEX35 TPT1 TRIM28 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 VRK1 WSB1 YY1AP1 ZBTB17 ZNF197 ZNF200 ZNF512B ZNF668 ZNF827
Entrez ID		3066	7428
HPRD ID		05521	01905
Ensembl ID		ENSG00000196591	ENSG00000134086
Uniprot IDs		Q92769	A0A024R2F2 A0A0S2Z4K1 A0A8Q3WL21 P40337
PDB IDs		3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6WHN 6WHO 6WHQ 6WHZ 6WI3 6XDM 6XEB 6XEC 7JS8 7KBG 7KBH 7LTG 7LTK 7LTL 7MOS 7MOT 7MOX 7MOY 7MOZ 7ZZO 7ZZP 7ZZR 7ZZS 7ZZT 7ZZU 7ZZW 8A0B 8BPA 8BPB 8BPC 8C60 9DTQ	1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC 7CJB 7JTO 7JTP 7KHH 7PI4 7Q2J 7S4E 7Z6L 7Z76 7Z77 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8EI3 8EWV 8FY0 8FY1 8FY2 8G1P 8G1Q 8P0F 8PC2 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8VL9 8VLB 8WDK 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9EQJ 9EQM 9IPW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Chromatin Remodeling DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Sin3-type Complex Histone Deacetylase Binding Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Transcription Repressor Complex Negative Regulation Of Developmental Process Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Protein-containing Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation	Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Post-translational Protein Modification Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Cytosol Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Macromolecule Metabolic Process Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Stability Chromatin Remodeling Positive Regulation Of Biosynthetic Process NF-kappaB Binding Response To Stress Negative Regulation Of Apoptotic Process Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?