HDAC2 and RCOR1

Number of citations of the paper that reports this interaction (PMID 11171972)
105

Data Source:
HPRD (in vitro, in vivo)

		HDAC2	RCOR1
Gene Name		histone deacetylase 2	REST corepressor 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Transcription Factor Complex Cytoplasm Sin3 Complex NuRD Complex ESC/E(Z) Complex Protein Complex	Nucleus Nucleoplasm Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Maintenance Of Chromatin Silencing Transcription, DNA-templated Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Hippocampus Development Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Regulation Of Gene Expression, Epigenetic Response To Cocaine Odontogenesis Of Dentin-containing Tooth Response To Drug Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Sarcomere Organization Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Blood Coagulation Viral Process Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Histone H4 Deacetylation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NoRC negatively regulates rRNA expression Signaling by NOTCH1 Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Chromatin organization HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 RNA Polymerase I Transcription Signaling by NOTCH Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression p75 NTR receptor-mediated signalling Factors involved in megakaryocyte development and platelet production NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		92 interactors: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LINC00152 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUV39H1 SYK TFCP2 THRA THRB TOP2A TOP2B TP53 VHL YY1 ZBTB16 ZNF461	10 interactors: CTBP1 HDAC2 HIST3H3 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 ZMYM2
Entrez ID		3066	23186
HPRD ID		05521	09645
Ensembl ID		ENSG00000196591	ENSG00000089902
Uniprot IDs		Q92769	J3KN32 Q9UKL0
PDB IDs		3MAX 4LXZ 4LY1	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Modification Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Organelle Organization Histone Modification Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Histone Deacetylation Protein Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Cycle	Chromosome Organization Chromatin Modification Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone Modification Nitrogen Compound Metabolic Process Histone H4 Deacetylation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Organelle Organization Biosynthetic Process Regulation Of Hormone Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process
Tagcloud ?		abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates gfi gfi1b h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?