HDAC2 and SMAD2

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HDAC2	SMAD2
Description		histone deacetylase 2	SMAD family member 2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Coregulator Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Histone Binding Histone Deacetylase Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding SMAD Binding Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Organization Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuron Projection Development Dendrite Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Caffeine Heterochromatin Formation Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Nicotine Protein Modification Process Response To Cocaine Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Progesterone Receptor Signaling Pathway Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Positive Regulation Of Male Mating Behavior Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine Response To Amyloid-beta Regulation Of Stem Cell Differentiation	Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regionalization Determination Of Left/right Asymmetry In Lateral Mesoderm Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Gastrulation Pattern Specification Process Endoderm Development Mesoderm Development Heart Development Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Secretion Cell Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Multicellular Organismal Process Pericardium Development SMAD Protein Signal Transduction Mesenchyme Development Trophoblast Cell Migration Secondary Palate Development Response To Cholesterol Response To Transforming Growth Factor Beta Odontoblast Differentiation
Pathways		p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm
Drugs		Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide	Dexfosfoserine
Diseases			Colorectal cancer
GWAS		Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)	Coronary artery disease in type 1 diabetes ( 29695241) Daytime nap ( 33568662) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)
Interacting Genes		97 interacting genes: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CEBPA CHFR CIRSR CSNK2A1 CSNK2A2 CTBP1 CUL4B CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX IFRD1 IKZF1 IKZF4 ING1 JUP MAD1L1 MBD2 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TMEM132D TOP2A TOP2B TP53 UBC USP4 VHL YY1 ZBTB16 ZNF461	220 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46P CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 DYRK1A E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6
Entrez ID		3066	4087
HPRD ID		05521	03221
Ensembl ID		ENSG00000196591	ENSG00000175387
Uniprot IDs		Q92769	B7Z5N5 Q15796 Q53XR6
PDB IDs		3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6WHN 6WHO 6WHQ 6WHZ 6WI3 6XDM 6XEB 6XEC 7JS8 7KBG 7KBH 7LTG 7LTK 7LTL 7MOS 7MOT 7MOX 7MOY 7MOZ 7ZZO 7ZZP 7ZZR 7ZZS 7ZZT 7ZZU 7ZZW 8A0B 8BPA 8BPB 8BPC 8C60 9DTQ	1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R 6M64 6YIA 6ZVQ 7CO1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Chromatin Remodeling DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Sin3-type Complex Histone Deacetylase Binding Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Transcription Repressor Complex Negative Regulation Of Developmental Process Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Protein-containing Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Binding Regulation Of Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Developmental Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Chromatin Negative Regulation Of Signaling Negative Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process
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