CSTF1

Description		cleavage stimulation factor subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage Stimulating Factor Complex
	Molecular Function	RNA Binding Protein Binding
	Biological Process	MRNA Processing MRNA 3'-end Processing
Pathways		mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323)
Interacting Genes		12 interacting genes: BARD1 BRCA1 CSTF3 H2AC20 MIR140 MIR206 MIR92A2 MIRLET7A3 MIRLET7I POLR2A VCP WEE2-AS1
Entrez ID		1477
HPRD ID		02653
Ensembl ID		ENSG00000101138
Uniprot IDs		Q05048
PDB IDs		6B3X
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Negative Regulation Of Gene Expression Nuclear Ubiquitin Ligase Complex BRCA1-C Complex MRNA Base-pairing Post-transcriptional Repressor Activity BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Post-transcriptional Regulation Of Gene Expression DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Postreplication Repair Homologous Recombination Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Interleukin-6 Production Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Flavin Adenine Dinucleotide Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of MRNA Metabolic Process MRNA Cleavage Stimulating Factor Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Intracellular Signal Transduction RNA-directed RNA Polymerase Activity
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