CSTF1 and CSTF3

Number of citations of the paper that reports this interaction (PMID 10669729)
78

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		CSTF1	CSTF3
Gene Name		cleavage stimulation factor, 3 pre-RNA, subunit 1, 50kDa	cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding	RNA Binding MRNA Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Processing RNA Splicing Gene Expression MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs	mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BARD1 BRCA1 CSTF3 POLR2A TOLLIP	4 interactors: CPSF1 CSTF1 CSTF2 RRAGA
Entrez ID		1477	1479
HPRD ID		02653	02651
Ensembl ID		ENSG00000101138	ENSG00000176102
Uniprot IDs		Q05048	Q12996
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K6-linked Ubiquitination DNA Repair Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription, RNA-templated Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To DNA Damage Stimulus Protein Polyubiquitination Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation DNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Protein Localization To Endosome Positive Regulation Of Metabolic Process Response To Stress RNA Splicing Cellular Response To Stress Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Protein Sumoylation MRNA Processing Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Negative Regulation Of Cell Cycle Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Acetylation MRNA Cleavage Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Regulation Of Protein Sumoylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair	MRNA Cleavage MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Phosphodiester Bond Hydrolysis RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Transcription From RNA Polymerase II Promoter Positive Regulation Of Cytolysis Transcription, DNA-templated Positive Regulation Of TOR Signaling Modulation By Virus Of Host Morphology Or Physiology RNA Biosynthetic Process RNA Metabolic Process Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Gene Expression MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Interaction With Host Regulation Of Autophagy
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