NHERF4 and PTGIR

Number of citations: 0 (PubMedID 22884631)
Data Source: BioGRID (two hybrid, affinity chromatography technology, imaging technique)

		NHERF4	PTGIR
Name		NHERF family PDZ scaffold protein 4	prostaglandin I2 receptor
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Cytosol Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Intestinal infectious diseases	Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events
Drugs		None	Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
GWAS		No GWAS studies recorded	Crohn's disease ( 28067908 )
Novel Interactors		3 novel interactors: FCER1G NLRX1 NOMO1	None recorded
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 NHERF4 PDE6D PRKCA RAB11A TBXA2R
Entrez ID		79849	5739
HPRD ID		06191	08959
Ensembl ID		ENSG00000172367	ENSG00000160013
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	P43119
PDB IDs		2V90	8X79 8X7A
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Guanyl Nucleotide Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity G-protein Beta/gamma-subunit Complex Binding Cellular Response To PH Heterotrimeric G-protein Complex Response To PH Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Regulation Of Establishment Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Muscle System Process Response To Alcohol GTPase Activity Phototransduction, Visible Light GTP Binding G Protein-coupled Receptor Signaling Pathway Cellular Response To Acidic PH G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Detection Of Visible Light Regulation Of Protein Localization Regulation Of Insulin Secretion Entrainment Of Circadian Clock Enzyme Regulator Activity Response To Acidic PH Response To Prostaglandin E Regulation Of Muscle Contraction Regulation Of Biological Quality Nucleotide Binding Regulation Of Peptide Hormone Secretion Regulation Of System Process Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Platelet Activation Regulation Of Body Fluid Levels Detection Of Light Stimulus Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Synaptic Vesicle Endosomal Processing Bicarbonate Binding Guanylate Cyclase Inhibitor Activity Plasma Membrane