PTGIR and TBXA2R

Number of citations of the paper that reports this interaction (PMID 20522800)
10

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		PTGIR	TBXA2R
Gene Name		prostaglandin I2 (prostacyclin) receptor (IP)	thromboxane A2 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation	Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Blood Coagulation Second-messenger-mediated Signaling Platelet Activation Response To Lipopolysaccharide Thromboxane A2 Signaling Pathway Response To Drug Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostacyclin signalling through prostacyclin receptor Signaling by GPCR G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Prostanoid ligand receptors GPCR downstream signaling Platelet homeostasis Eicosanoid ligand-binding receptors	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Signal amplification GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (12/13) signalling events Platelet activation, signaling and aggregation Eicosanoid ligand-binding receptors
Drugs		Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol	Ridogrel
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	24 interactors: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNB2L1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKACA PRKCA PRKG1 PSMA7 PSME3 PTGIR RAB11A RAF1 RPGRIP1L YWHAZ
Entrez ID		5739	6915
HPRD ID		08959	01768
Ensembl ID		ENSG00000160013	ENSG00000006638
Uniprot IDs		P43119	P21731 Q05C92 Q0VAB0
PDB IDs			1LBN
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Water Transport Fluid Transport Wound Healing Regulation Of Cyclase Activity Cell Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Wounding Regulation Of Melanocyte Differentiation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger CAMP Biosynthetic Process Regulation Of Developmental Pigmentation Negative Regulation Of Lyase Activity G-protein Coupled Receptor Signaling Pathway Skeletal System Development Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Protein Transport Positive Regulation Of Adenylate Cyclase Activity CAMP Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Nucleotide Metabolic Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Catalytic Activity Signal Transduction Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Protein Localization Cyclic Nucleotide Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Signaling Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Chemical Homeostasis Cell Communication Developmental Pigmentation Positive Regulation Of CAMP Metabolic Process	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Wound Healing G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Wounding Cell Activation Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Signal Transduction Positive Regulation Of CAMP Metabolic Process Signaling Cell Communication Regulation Of Signaling Dopamine Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Stimulus Negative Regulation Of Signal Transduction Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Intracellular Signal Transduction Regulation Of Cyclase Activity Response To Stress Cellular Response To Catecholamine Stimulus Activation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Response To Stimulus Cellular Response To Fatty Acid Positive Regulation Of Lyase Activity Positive Regulation Of Signal Transduction Apoptotic Process Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Response To Glucagon Cellular Response To Prostaglandin E Stimulus Programmed Cell Death Cell Death Negative Regulation Of Transferase Activity
Tagcloud ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1	alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype haplotypes homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes
Tagcloud (Difference) ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1	alleles asthma beas bronchodilator bsmcs disequilibrium eosinophil expiratory fef fev1 forced fvc h2 haplotype homozygotes redefined remodelling rs1131882 rs2238631 rs2238632 rs2238633 rs2238634 snp1 snp2 snp3 snp4 thromboxane zygotes
Tagcloud (Intersection) ?		haplotypes