NHERF4 and SLC15A1

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		NHERF4	SLC15A1
Description		NHERF family PDZ scaffold protein 4	solute carrier family 15 member 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Brush Border Membrane Apical Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Proton-dependent Oligopeptide Secondary Active Transmembrane Transporter Activity Symporter Activity Peptide:proton Symporter Activity Transmembrane Transporter Activity Oligopeptide Transmembrane Transporter Activity Tripeptide Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Monoatomic Ion Transport Oligopeptide Transport Protein Transport Peptide Transport Transmembrane Transport Dipeptide Import Across Plasma Membrane Tripeptide Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Intestinal infectious diseases	Proton/oligopeptide cotransporters
Drugs			Ampicillin Phenoxymethylpenicillin Cefotaxime Oxacillin Benzylpenicillin Ceftriaxone Benzoic acid Dexibuprofen
Diseases
GWAS			Blood urea nitrogen levels ( 29403010) Educational attainment ( 25201988) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	2 interacting genes: NHERF4 USP7
Entrez ID		79849	6564
HPRD ID		06191	02768
Ensembl ID		ENSG00000172367	ENSG00000088386
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	B2CQT6 P46059
PDB IDs		2V90	7PMW 7PMX 7PN1
Enriched GO Terms of Interacting Partners?		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of CGMP-mediated Signaling Guanylate Cyclase Inhibitor Activity Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Receptor Guanylyl Cyclase Signaling Pathway Regulation Of CGMP-mediated Signaling Ion Channel Inhibitor Activity Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Negative Regulation Of Intracellular Signal Transduction K48-linked Deubiquitinase Activity Ubiquitin-specific Protease Binding Deubiquitinase Activity Water Transport Apical Junction Complex Protein-membrane Adaptor Activity Fluid Transport Nucleotide-excision Repair Negative Regulation Of Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Gluconeogenesis Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Cysteine-type Endopeptidase Activity Negative Regulation Of Signaling Brush Border P53 Binding Cysteine-type Deubiquitinase Activity Protein Deubiquitination Autophagosome Assembly Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucose Metabolic Process Apical Part Of Cell Response To Toxic Substance Autophagosome Organization Negative Regulation Of Autophagy Regulation Of Telomere Maintenance PML Body
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