NHERF4 and SLC22A3

Number of citations of the paper that reports this interaction (PubMedID 15553237)
0

Data Source:
HPRD (two hybrid)

		NHERF4	SLC22A3
Description		NHERF family PDZ scaffold protein 4	solute carrier family 22 member 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Nucleus Nuclear Outer Membrane Mitochondrion Plasma Membrane Basal Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Apical Plasma Membrane Nuclear Membrane Mitochondrial Membrane Neuronal Cell Body Presynapse
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Neurotransmitter Transmembrane Transporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Histamine Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Serotonin Transport Organic Cation Transport Quaternary Ammonium Group Transport Organic Anion Transport Monocarboxylic Acid Transport Monoamine Transport Spermidine Transport Organic Hydroxy Compound Transport Dopamine Transport Norepinephrine Transport Regulation Of Appetite Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Epinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Purine-containing Compound Transmembrane Transport Dopamine Uptake Transport Across Blood-brain Barrier Spermidine Transmembrane Transport Cellular Detoxification
Pathways		Intestinal infectious diseases	Abacavir transmembrane transport SLC-mediated transport of organic cations
Drugs
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) Body fat percentage and LDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 28892062 26426971) Body mass index (age>50) ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and LDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index x sex x age interaction (4df test) ( 26426971) Colorectal cancer ( 21242260) Coronary artery disease ( 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611) Estimated glomerular filtration rate ( 31015462) Glycine levels ( 30837465) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma plasminogen levels ( 25208887) Prostate cancer ( 26034056 18264097 27262462 25939597) Pulse pressure ( 30224653) Response to hepatitis C treatment ( 22095909) Type 2 diabetes ( 30297969 30054458 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	1 interacting genes: NHERF4
Entrez ID		79849	6581
HPRD ID		06191	05328
Ensembl ID		ENSG00000172367	ENSG00000146477
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	O75751
PDB IDs		2V90	7ZH0 7ZH6 7ZHA
Enriched GO Terms of Interacting Partners?		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Guanylate Cyclase Inhibitor Activity Negative Regulation Of CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Regulation Of CGMP-mediated Signaling Ion Channel Inhibitor Activity Ubiquitin-specific Protease Binding Apical Junction Complex Protein-membrane Adaptor Activity Fluid Transport Water Transport Brush Border Apical Part Of Cell Response To Toxic Substance Protein Localization To Plasma Membrane Protein Localization To Cell Periphery
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