PDZD3 and CACNA1S

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDZD3	CACNA1S
Gene Name		PDZ domain containing 3	calcium channel, voltage-dependent, L type, alpha 1S subunit
Image
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Subapical Complex Apical Part Of Cell	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Sarcoplasmic Reticulum T-tubule I Band
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity	Skeletal System Development Extraocular Skeletal Muscle Development Calcium Ion Transport Muscle Contraction Striated Muscle Contraction Endoplasmic Reticulum Organization Axon Guidance Myoblast Fusion Neuromuscular Junction Development Regulation Of Ion Transmembrane Transport Skeletal Muscle Adaptation Skeletal Muscle Fiber Development Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Permanent tooth development ( 21931568)
Protein-Protein Interactions		17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	4 interactors: PDZD3 RIMS2 RYR1 SRI
Entrez ID		79849	779
HPRD ID		06191	00248
Ensembl ID		ENSG00000172367	ENSG00000081248
Uniprot IDs		B0YJ61 Q86UT5	B1ALM3 Q13698
PDB IDs		2V90	2VAY
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis	Cyclic-nucleotide-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Intracellular Sequestering Of Iron Ion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Membrane Potential Muscle Organ Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transport Regulation Of High Voltage-gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Relaxation Of Muscle Ion Transport Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Cellular Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Cellular Response To Caffeine Regulation Of Ion Transmembrane Transport Transport Cellular Cation Homeostasis Regulation Of Cell Communication By Electrical Coupling Cellular Ion Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Metal Ion Homeostasis Negative Regulation Of Transcription Regulatory Region DNA Binding Muscle Structure Development Heart Development Ossification Involved In Bone Maturation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Chemical Homeostasis Bone Maturation Ion Homeostasis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Regulation Of CGMP Biosynthetic Process CAMP-mediated Signaling Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Negative Regulation Of Lyase Activity Cellular Localization Regulation Of Ion Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Tagcloud ?			aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Difference) ?			aftn autonomously carry channel defects encoding familial former functioning graves gs gsalpha herein hypokalemic japanese kcne3 latter nodule paralysis periodic potassium rarely resolved stimulatory thyrotoxic thyrotropin tpp tshr understood
Tagcloud (Intersection) ?