NHERF4 and SLCO1A2

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		NHERF4	SLCO1A2
Name		NHERF family PDZ scaffold protein 4	solute carrier organic anion transporter family member 1A2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Xenobiotic Metabolic Process Monoatomic Ion Transport Lipid Transport Organic Cation Transport Organic Anion Transport Bile Acid And Bile Salt Transport Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways		Intestinal infectious diseases	Recycling of bile acids and salts Organic anion transport by SLCO transporters Ciprofloxacin ADME
GWAS		No GWAS studies recorded	AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875 ) Bilirubin levels ( 19414484 ) Diisocyanate-induced asthma ( 25918132 ) Methotrexate pharmacokinetics (acute lymphoblastic leukemia) ( 19901119 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Progressive supranuclear palsy ( 21685912 30089514 ) Rocuronium dose requirement in breast cancer surgery ( 33676726 ) Serum metabolite levels ( 23093944 ) Statin-induced myopathy (severe) ( 31220337 )
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1
Entrez ID		79849	6579
HPRD ID		06191	09112
Ensembl ID		ENSG00000172367	ENSG00000084453
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	B4DJE6 P46721
PDB IDs		2V90	Not available
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Type 3 Metabotropic Glutamate Receptor Binding Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Cellular Localization Brush Border Membrane Phosphatase Binding Brush Border Intracellular Protein Localization PDZ Domain Binding Apical Part Of Cell Beta-catenin Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Molecular Adaptor Activity Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Endomembrane System Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Monoatomic Anion Transport Xenobiotic Export From Cell Quaternary Ammonium Group Transport