NHERF4 and SLC22A5

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		NHERF4	SLC22A5
Name		NHERF family PDZ scaffold protein 4	solute carrier family 22 member 5
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Binding ATP Binding Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity (R)-carnitine Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Monoatomic Ion Transport Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Response To Type II Interferon Response To Tumor Necrosis Factor Xenobiotic Transport Transmembrane Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Transport Across Blood-brain Barrier (R)-carnitine Transport (R)-carnitine Transmembrane Transport Carnitine Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Intestinal infectious diseases	Carnitine shuttle SLC-mediated transport of organic cations Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs		None	Levocarnitine
Diseases		None	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Crohn's disease
GWAS		No GWAS studies recorded	Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31959851 31619474 29273806 20860503 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Carotid plaque maximum area ( 32469969 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 28067908 ) Diastolic blood pressure ( 30578418 ) Fibrinogen ( 20031577 ) Height ( 20881960 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Inflammatory bowel disease ( 23128233 28067908 ) Intracranial aneurysm ( 33199917 ) Low density lipoprotein cholesterol levels ( 29083408 32154731 ) Maximum stenosis ( 32469969 ) Mean area of carotid plaque ( 32469969 ) Mean degree of stenosis ( 32469969 ) Mean platelet volume ( 32888494 ) Monocyte count ( 32888494 ) Mosquito bite size ( 28199695 ) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311 ) Serum metabolite levels ( 23093944 33031748 ) Subcortical volume (MOSTest) ( 32665545 ) Sum of carotid plaque area ( 32469969 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 32888494 )
Novel Interactors		3 novel interactors: FCER1G NLRX1 NOMO1	None recorded
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	11 interacting genes: KRT27 KRT34 KRTAP6-3 MTUS2 NBPF19 NHERF1 NHERF2 NHERF4 NOTCH2NLA PDZK1 SH3RF1
Entrez ID		79849	6584
HPRD ID		06191	04539
Ensembl ID		ENSG00000172367	ENSG00000197375
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	O76082
PDB IDs		2V90	Not available
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Intermediate Filament Microvillus Membrane Localization Within Membrane Structural Constituent Of Skin Epidermis Brush Border Membrane Brush Border Phosphatase Binding Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Intermediate Filament Organization Morphogenesis Of An Epithelium PDZ Domain Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Apical Part Of Cell Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Epithelial Cell Differentiation Tissue Morphogenesis Beta-catenin Binding Scavenger Receptor Binding Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of CGMP-mediated Signaling Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Structural Molecule Activity Intracellular Phosphate Ion Homeostasis