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NHERF4 and SLC22A5
Number of citations of the paper that reports this interaction (PubMedID
15553237
)
0
Data Source:
HPRD
(two hybrid)
NHERF4
SLC22A5
Description
NHERF family PDZ scaffold protein 4
solute carrier family 22 member 5
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Brush Border
Membrane
Apical Plasma Membrane
Apical Junction Complex
Apical Part Of Cell
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Basal Plasma Membrane
Membrane
Apical Plasma Membrane
Brush Border Membrane
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Protein Binding
Ion Channel Inhibitor Activity
Guanylate Cyclase Inhibitor Activity
Protein-membrane Adaptor Activity
Ubiquitin-specific Protease Binding
Nucleotide Binding
Protein Binding
ATP Binding
Amino-acid Betaine Transmembrane Transporter Activity
Carnitine Transmembrane Transporter Activity
Symporter Activity
Quaternary Ammonium Group Transmembrane Transporter Activity
Transmembrane Transporter Activity
PDZ Domain Binding
Xenobiotic Transmembrane Transporter Activity
(R)-carnitine Transmembrane Transporter Activity
Biological Process
Monoatomic Ion Transport
Water Transport
Receptor Guanylyl Cyclase Signaling Pathway
Response To Toxic Substance
Negative Regulation Of CGMP-mediated Signaling
Protein Localization To Plasma Membrane
Monoatomic Ion Transport
Sodium Ion Transport
Response To Symbiotic Bacterium
Quaternary Ammonium Group Transport
Carnitine Transport
Response To Type II Interferon
Response To Tumor Necrosis Factor
Xenobiotic Transport
Transmembrane Transport
Positive Regulation Of Intestinal Epithelial Structure Maintenance
Sodium-dependent Organic Cation Transport
Transport Across Blood-brain Barrier
(R)-carnitine Transport
(R)-carnitine Transmembrane Transport
Carnitine Transmembrane Transport
Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways
Intestinal infectious diseases
Carnitine shuttle
SLC-mediated transport of organic cations
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs
Levocarnitine
Diseases
Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
Crohn's disease
GWAS
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
31619474
29273806
20860503
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Brain morphology (MOSTest) (
32665545
)
Carotid plaque maximum area (
32469969
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
21102463
28067908
)
Diastolic blood pressure (
30578418
)
Fibrinogen (
20031577
)
Height (
20881960
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
23128233
28067908
)
Intracranial aneurysm (
33199917
)
Low density lipoprotein cholesterol levels (
29083408
32154731
)
Maximum stenosis (
32469969
)
Mean area of carotid plaque (
32469969
)
Mean degree of stenosis (
32469969
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Mosquito bite size (
28199695
)
Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) (
24823311
)
Serum metabolite levels (
23093944
33031748
)
Subcortical volume (MOSTest) (
32665545
)
Sum of carotid plaque area (
32469969
)
Ulcerative colitis (
28067908
)
White blood cell count (
32888494
)
Interacting Genes
18 interacting genes:
ABCC2
ASAP3
CACNA1S
CFTR
GUCY2C
PTGIR
SLC15A1
SLC15A2
SLC22A3
SLC22A4
SLC22A5
SLC22A9
SLC41A3
SLCO1A2
SLCO1C1
SLCO3A1
SPRYD7
TAS2R8
11 interacting genes:
KRT27
KRT34
KRTAP6-3
MTUS2
NBPF19
NHERF1
NHERF2
NHERF4
NOTCH2NLA
PDZK1
SH3RF1
Entrez ID
79849
6584
HPRD ID
06191
04539
Ensembl ID
ENSG00000172367
ENSG00000197375
Uniprot IDs
B0YJ61
E9PPZ1
Q86UT5
O76082
PDB IDs
2V90
Enriched GO Terms of Interacting Partners
?
Organic Anion Transmembrane Transporter Activity
Transmembrane Transporter Activity
Transmembrane Transport
Monoatomic Ion Transport
Apical Plasma Membrane
Sodium-independent Organic Anion Transport
Sodium-independent Organic Anion Transmembrane Transporter Activity
Transport Across Blood-brain Barrier
Xenobiotic Transport
Organic Anion Transport
Monocarboxylic Acid Transport
Carboxylic Acid Transport
Organic Acid Transport
Basal Plasma Membrane
Quaternary Ammonium Group Transmembrane Transporter Activity
Plasma Membrane
Organic Hydroxy Compound Transport
Organic Cation Transmembrane Transporter Activity
Basolateral Plasma Membrane
Quaternary Ammonium Group Transport
Xenobiotic Export From Cell
Vascular Process In Circulatory System
Lipid Transport
Tripeptide Transmembrane Transporter Activity
Tripeptide Import Across Plasma Membrane
Oligopeptide Transmembrane Transporter Activity
Circulatory System Process
Membrane
Bile Acid And Bile Salt Transport
Organic Cation Transport
Amino-acid Betaine Transmembrane Transporter Activity
Symporter Activity
Dipeptide Transmembrane Transporter Activity
Peptide:proton Symporter Activity
Carnitine Transmembrane Transporter Activity
Dipeptide Transport
Dipeptide Import Across Plasma Membrane
Dipeptide Transmembrane Transport
Import Across Plasma Membrane
Carnitine Transport
Carnitine Transmembrane Transport
Bile Acid Transmembrane Transporter Activity
ATPase-coupled Inorganic Anion Transmembrane Transporter Activity
Import Into Cell
Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Amino-acid Betaine Transport
Serotonin Transport
PDZ Domain Binding
Oligopeptide Transmembrane Transport
Oligopeptide Transport
Protein-membrane Adaptor Activity
Type 2 Metabotropic Glutamate Receptor Binding
Type 3 Metabotropic Glutamate Receptor Binding
Protein Localization To Plasma Membrane
Protein Localization To Cell Periphery
Protein Localization To Membrane
Apical Plasma Membrane
Signaling Receptor Binding
Intermediate Filament
Microvillus Membrane
Localization Within Membrane
Structural Constituent Of Skin Epidermis
Brush Border Membrane
Brush Border
Phosphatase Binding
Renal Phosphate Ion Absorption
Guanylate Cyclase Inhibitor Activity
Intermediate Filament Organization
Morphogenesis Of An Epithelium
PDZ Domain Binding
Regulation Of Renal Phosphate Excretion
Dopamine Receptor Binding
Apical Part Of Cell
Intermediate Filament Cytoskeleton Organization
Keratin Filament
Intermediate Filament-based Process
Epithelial Cell Differentiation
Tissue Morphogenesis
Beta-catenin Binding
Scavenger Receptor Binding
Growth Factor Receptor Binding
Carnitine Transmembrane Transport
Carnitine Transport
Maintenance Of Epithelial Cell Apical/basal Polarity
Bile Acid Secretion
Microvillus Assembly
Channel Activator Activity
Gamma-aminobutyric Acid Transmembrane Transporter Activity
Beta-2 Adrenergic Receptor Binding
Chloride Channel Regulator Activity
Gamma-aminobutyric Acid Import
Negative Regulation Of CGMP-mediated Signaling
Microvillus Organization
Establishment Of Golgi Localization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Structural Molecule Activity
Intracellular Phosphate Ion Homeostasis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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