PTGIR and GNA11

Number of citations of the paper that reports this interaction (PubMedID 10446129)
0

Data Source:
HPRD (in vitro)

		PTGIR	GNA11
Description		prostaglandin I2 receptor	G protein subunit alpha 11
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Skeletal System Development Action Potential Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Regulation Of Blood Pressure Entrainment Of Circadian Clock Positive Regulation Of Insulin Secretion Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH Endothelin Receptor Signaling Pathway Cranial Skeletal System Development Ligand-gated Ion Channel Signaling Pathway
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)	Asthma ( 31959851)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 NHERF4 PDE6D PRKCA RAB11A TBXA2R	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A NHERF1 PTGIR RGS14 RGS3 TBXA2R TRPC3 TSHR
Entrez ID		5739	2767
HPRD ID		08959	00759
Ensembl ID		ENSG00000160013	ENSG00000088256
Uniprot IDs		P43119	P29992
PDB IDs		8X79 8X7A	6OIJ 7RKF 7TRY 7XXH
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity G-protein Beta/gamma-subunit Complex Binding Cellular Response To PH Heterotrimeric G-protein Complex Response To PH Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Regulation Of Establishment Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Muscle System Process Response To Alcohol GTPase Activity Phototransduction, Visible Light GTP Binding G Protein-coupled Receptor Signaling Pathway Cellular Response To Acidic PH G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Detection Of Visible Light Regulation Of Protein Localization Regulation Of Insulin Secretion Entrainment Of Circadian Clock Enzyme Regulator Activity Response To Acidic PH Response To Prostaglandin E Regulation Of Muscle Contraction Regulation Of Biological Quality Nucleotide Binding Regulation Of Peptide Hormone Secretion Regulation Of System Process Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Platelet Activation Regulation Of Body Fluid Levels Detection Of Light Stimulus Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Synaptic Vesicle Endosomal Processing Bicarbonate Binding Guanylate Cyclase Inhibitor Activity Plasma Membrane	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Smooth Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Vascular Process In Circulatory System Circulatory System Process G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Signal Transduction Vasoconstriction Plasma Membrane Muscle Contraction Regulation Of Blood Circulation Muscle System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Biological Quality Inorganic Ion Homeostasis Membrane System Process Regulation Of Vasoconstriction Vascular Associated Smooth Muscle Contraction Regulation Of Cell Communication Regulation Of Signaling Endothelin Receptor Activity Calcium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of MAPK Cascade Calcium Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Calcium Ion Transport Regulation Of Muscle System Process Regulation Of Intracellular Signal Transduction Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Renal Albumin Absorption G Protein-coupled Serotonin Receptor Complex Regulation Of ERK1 And ERK2 Cascade Ameboidal-type Cell Migration Positive Regulation Of Multicellular Organismal Process Type 1 Angiotensin Receptor Binding Chemical Homeostasis Renal Absorption
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