NHERF4 and SLC22A4

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		NHERF4	SLC22A4
Name		NHERF family PDZ scaffold protein 4	solute carrier family 22 member 4
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Mitochondrion Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Mitochondrial Membrane Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Acetylcholine Transmembrane Transporter Activity Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Amino-acid Betaine Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Sulfur Amino Acid Transport Triglyceride Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Neurotransmitter Transport Lactation Carnitine Metabolic Process Quaternary Ammonium Group Transport Carnitine Transport Response To Lipopolysaccharide Response To Vitamin D Xenobiotic Transport Response To Exogenous DsRNA Acetylcholine Uptake Transmembrane Transport Amino Acid Import Across Plasma Membrane Liver Regeneration Carnitine Transmembrane Transport
Pathways		Intestinal infectious diseases	SLC-mediated transport of organic cations
Drugs		None	Levocarnitine
Diseases		None	Crohn's disease
GWAS		No GWAS studies recorded	Asthma ( 31619474 ) Asthma (sex interaction) ( 24824216 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 21102463 22412388 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Fibrinogen ( 20031577 ) Fibrinogen levels ( 26561523 ) Granulocyte count ( 27863252 ) Immature fraction of reticulocytes ( 27863252 ) Inflammatory bowel disease ( 28067908 23128233 ) Intracranial aneurysm ( 33199917 ) Itch intensity from mosquito bite ( 28199695 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 27863252 ) Metabolic traits ( 21886157 ) Monocyte count ( 27863252 ) Myeloid white cell count ( 27863252 ) Myocardial infarction ( 33532862 ) Nasal polyps ( 30643255 ) Neutrophil count ( 27863252 ) Platelet count ( 32888494 ) Serum metabolite levels ( 23093944 33031748 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) White blood cell count ( 27863252 )
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	4 interacting genes: NHERF1 NHERF2 NHERF4 PDZK1
Entrez ID		79849	6583
HPRD ID		06191	09171
Ensembl ID		ENSG00000172367	ENSG00000197208
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	Q9H015
PDB IDs		2V90	Not available
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Protein-membrane Adaptor Activity Protein Localization To Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Cell Periphery Type 3 Metabotropic Glutamate Receptor Binding Protein Localization To Membrane Apical Plasma Membrane Signaling Receptor Binding Localization Within Membrane Microvillus Membrane Brush Border Membrane Phosphatase Binding Brush Border PDZ Domain Binding Cellular Localization Apical Part Of Cell Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Beta-catenin Binding Intracellular Protein Localization Susceptibility To T Cell Mediated Cytotoxicity Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Susceptibility To Natural Killer Cell Mediated Cytotoxicity Scavenger Receptor Binding Molecular Adaptor Activity Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Endomembrane System Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Transporter Activator Activity Glutathione Transport