PDZD3 and SLC22A4

Number of citations of the paper that reports this interaction (PMID 15553237)
5

Data Source:
HPRD (two hybrid)

		PDZD3	SLC22A4
Gene Name		PDZ domain containing 3	solute carrier family 22 (organic cation/zwitterion transporter), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Subapical Complex Apical Part Of Cell	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity	Nucleotide Binding Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Cation:cation Antiporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity	Triglyceride Metabolic Process Sodium Ion Transport Body Fluid Secretion Carnitine Metabolic Process Organic Cation Transport Quaternary Ammonium Group Transport Carnitine Transport Transmembrane Transport Carnitine Transmembrane Transport
Pathways			Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs			L-Carnitine
Diseases
GWAS			Crohn's disease ( 22412388 21102463) Fibrinogen ( 20031577) Inflammatory bowel disease ( 23128233) Metabolic traits ( 21886157)
Protein-Protein Interactions		17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	4 interactors: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2
Entrez ID		79849	6583
HPRD ID		06191	09171
Ensembl ID		ENSG00000172367	ENSG00000197208
Uniprot IDs		B0YJ61 Q86UT5	Q9H015
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of CGMP Biosynthetic Process Renal Phosphate Ion Absorption Negative Regulation Of Guanylate Cyclase Activity Monocarboxylic Acid Transport Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Sodium Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Ion Transport Bile Acid Secretion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Oligopeptide Transport Carnitine Transport Organic Anion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Regulation Of Ion Transport Regulation Of Excretion Monovalent Inorganic Cation Transport Anion Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Cyclic-nucleotide-mediated Signaling Bile Acid And Bile Salt Transport Regulation Of CGMP Metabolic Process Positive Regulation Of Protein Targeting To Membrane Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process
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