NHERF4 and SLC15A2

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		NHERF4	SLC15A2
Name		NHERF family PDZ scaffold protein 4	solute carrier family 15 member 2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Membrane Apical Plasma Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Protein Binding Symporter Activity Peptide:proton Symporter Activity Transmembrane Transporter Activity Oligopeptide Transmembrane Transporter Activity Tripeptide Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Immune System Process Oligopeptide Transport Protein Transport Peptide Transport Peptidoglycan Transport Xenobiotic Transport Dipeptide Transport Innate Immune Response Transmembrane Transport Renal Absorption Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Dipeptide Import Across Plasma Membrane Tripeptide Import Across Plasma Membrane Antibacterial Innate Immune Response Transport Across Blood-brain Barrier Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Intestinal infectious diseases	None
Drugs		None	Ampicillin Cefotaxime Oxacillin Benzylpenicillin
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708 ) Glomerular filtration rate ( 29403010 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Multiple sclerosis ( 21833088 ) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 )
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	26 interacting genes: ADAM12 ANKS1A AQP1 C11orf87 CHRD ENKD1 KLHL38 KPRP KRT34 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP6-3 LMO4 NHERF4 NTAQ1 OTX1 PDZK1 PITX1 PLSCR4 SMARCC1 TENT5B TLX3 VENTX WWOX
Entrez ID		79849	6565
HPRD ID		06191	09088
Ensembl ID		ENSG00000172367	ENSG00000163406
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	Q16348
PDB IDs		2V90	6EZI 7PMY
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Intermediate Filament Brush Border