PTGIR and PDZD3

Number of citations of the paper that reports this interaction (PMID 22884631)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, imaging technique)

		PTGIR	PDZD3
Gene Name		prostaglandin I2 (prostacyclin) receptor (IP)	PDZ domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Cytosol Brush Border Subapical Complex Apical Part Of Cell
	Molecular Function	G-protein Coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostacyclin signalling through prostacyclin receptor Signaling by GPCR G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Prostanoid ligand receptors GPCR downstream signaling Platelet homeostasis Eicosanoid ligand-binding receptors
Drugs		Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		5739	79849
HPRD ID		08959	06191
Ensembl ID		ENSG00000160013	ENSG00000172367
Uniprot IDs		P43119	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Water Transport Fluid Transport Wound Healing Regulation Of Cyclase Activity Cell Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Wounding Regulation Of Melanocyte Differentiation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger CAMP Biosynthetic Process Regulation Of Developmental Pigmentation Negative Regulation Of Lyase Activity G-protein Coupled Receptor Signaling Pathway Skeletal System Development Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Protein Transport Positive Regulation Of Adenylate Cyclase Activity CAMP Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Nucleotide Metabolic Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Catalytic Activity Signal Transduction Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Protein Localization Cyclic Nucleotide Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Signaling Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Chemical Homeostasis Cell Communication Developmental Pigmentation Positive Regulation Of CAMP Metabolic Process	Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis
Tagcloud ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Difference) ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Intersection) ?