PTGIR and NHERF4

Number of citations of the paper that reports this interaction (PubMedID 22884631)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology, imaging technique)

		PTGIR	NHERF4
Description		prostaglandin I2 receptor	NHERF family PDZ scaffold protein 4
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell
	Molecular Function	G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events	Intestinal infectious diseases
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 NHERF4 PDE6D PRKCA RAB11A TBXA2R	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8
Entrez ID		5739	79849
HPRD ID		08959	06191
Ensembl ID		ENSG00000160013	ENSG00000172367
Uniprot IDs		P43119	B0YJ61 E9PPZ1 Q86UT5
PDB IDs		8X79 8X7A	2V90
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity G-protein Beta/gamma-subunit Complex Binding Cellular Response To PH Heterotrimeric G-protein Complex Response To PH Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Regulation Of Establishment Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Muscle System Process Response To Alcohol GTPase Activity Phototransduction, Visible Light GTP Binding G Protein-coupled Receptor Signaling Pathway Cellular Response To Acidic PH G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Detection Of Visible Light Regulation Of Protein Localization Regulation Of Insulin Secretion Entrainment Of Circadian Clock Enzyme Regulator Activity Response To Acidic PH Response To Prostaglandin E Regulation Of Muscle Contraction Regulation Of Biological Quality Nucleotide Binding Regulation Of Peptide Hormone Secretion Regulation Of System Process Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Platelet Activation Regulation Of Body Fluid Levels Detection Of Light Stimulus Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Synaptic Vesicle Endosomal Processing Bicarbonate Binding Guanylate Cyclase Inhibitor Activity Plasma Membrane	Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport
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