NHERF4 and SPRYD7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NHERF4	SPRYD7
Description		NHERF family PDZ scaffold protein 4	SPRY domain containing 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane
Pathways		Intestinal infectious diseases
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	15 interacting genes: AGXT AQP1 CAMK2B HEMK1 NHERF4 NTAQ1 OTX1 POGZ TLX3 TRIM55 TRIM63 TRIP13 UBASH3A VAC14 YPEL3
Entrez ID		79849	57213
HPRD ID		06191	08486
Ensembl ID		ENSG00000172367	ENSG00000123178
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	A0A024RDT6 Q5W111
PDB IDs		2V90	7CCB
Enriched GO Terms of Interacting Partners?		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	L-serine-pyruvate Transaminase Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Fluid Transport Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Water Transport Diencephalon Morphogenesis Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity PAS Complex Guanylate Cyclase Inhibitor Activity
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