NHERF4 and ASAP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		NHERF4	ASAP3
Description		NHERF family PDZ scaffold protein 4	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Ruffle Nucleoplasm Cytoplasm Cytosol Focal Adhesion Intracellular Membrane-bounded Organelle
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Cell Migration Positive Regulation Of GTPase Activity Regulation Of Stress Fiber Assembly
Pathways		Intestinal infectious diseases
Drugs
Diseases
GWAS			Cholesterol, total ( 24097068) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Severe insulin-resistant type 2 diabetes ( 34737425) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	9 interacting genes: ARF6 CRK MTNR1A NHERF4 REL TCF4 TEPSIN TFCP2 UBE3A
Entrez ID		79849	55616
HPRD ID		06191	11662
Ensembl ID		ENSG00000172367	ENSG00000088280
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	A0AAA9YHE6 B4DRP2 Q8TDY4
PDB IDs		2V90	2B0O 3LVQ 3LVR
Enriched GO Terms of Interacting Partners?		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Response To Nerve Growth Factor Postsynaptic Specialization Organization Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein Localization To Membrane Cellular Response To Nerve Growth Factor Stimulus Sperm Entry Positive Regulation Of Golgi Lumen Acidification Guanylate Cyclase Inhibitor Activity Coated Vesicle Membrane Signaling Adaptor Activity Positive Regulation Of Protein Localization To Membrane Establishment Of Cell Polarity Regulation Of Dendrite Development Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Protein Localization Protein Localization To Cleavage Furrow Cerebellar Neuron Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Beta-catenin-TCF7L2 Complex Regulation Of Golgi Lumen Acidification Regulation Of Intracellular Signal Transduction Localization Within Membrane Melatonin Receptor Activity NF-kappaB Complex TFIIB-class Transcription Factor Binding
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