PTGIR and ADCY10

Number of citations of the paper that reports this interaction (PubMedID 10446129)
0

Data Source:
HPRD (in vitro)

		PTGIR	ADCY10
Description		prostaglandin I2 receptor	adenylate cyclase 10
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Motile Cilium Cell Projection Neuronal Cell Body Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Astrocyte End-foot
	Molecular Function	G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Lyase Activity Manganese Ion Binding Metal Ion Binding ATPase Binding Bicarbonate Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Glucose Catabolic Process CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Spermatid Development Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Axon Extension Positive Regulation Of Ossification Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Mitochondrial Depolarization Regulation Of Membrane Repolarization Neuron Projection Retraction Negative Regulation Of Cardiac Muscle Cell Contraction Regulation Of Mitophagy Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Neuron Projection Extension Neuron Projection Maintenance Mitochondrial ATP Transmembrane Transport Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events	Hedgehog 'off' state
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag	Colforsin
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 NHERF4 PDE6D PRKCA RAB11A TBXA2R	2 interacting genes: PTGIR SSTR5
Entrez ID		5739	55811
HPRD ID		08959	05549
Ensembl ID		ENSG00000160013	ENSG00000143199
Uniprot IDs		P43119	A0A0K0K1J8 Q96PN6
PDB IDs		8X79 8X7A	4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4 7OVD 8B75 8CNH 8CO7 8COJ 8COT 8IL7
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity G-protein Beta/gamma-subunit Complex Binding Cellular Response To PH Heterotrimeric G-protein Complex Response To PH Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Regulation Of Establishment Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Muscle System Process Response To Alcohol GTPase Activity Phototransduction, Visible Light GTP Binding G Protein-coupled Receptor Signaling Pathway Cellular Response To Acidic PH G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Detection Of Visible Light Regulation Of Protein Localization Regulation Of Insulin Secretion Entrainment Of Circadian Clock Enzyme Regulator Activity Response To Acidic PH Response To Prostaglandin E Regulation Of Muscle Contraction Regulation Of Biological Quality Nucleotide Binding Regulation Of Peptide Hormone Secretion Regulation Of System Process Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Platelet Activation Regulation Of Body Fluid Levels Detection Of Light Stimulus Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Synaptic Vesicle Endosomal Processing Bicarbonate Binding Guanylate Cyclase Inhibitor Activity Plasma Membrane	Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling Cellular Response To Hormone Stimulus TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Positive Regulation Of Cell Cycle Process Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of Cell Population Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation G Protein-coupled Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Positive Regulation Of Cell Cycle Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Response To Lipid Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Prostacyclin Receptor Activity G Protein-coupled Receptor Activity Somatostatin Signaling Pathway Somatostatin Receptor Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development
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