PTGIR and ADCY10

Number of citations of the paper that reports this interaction (PMID 10446129)
17

Data Source:
HPRD (in vitro)

		PTGIR	ADCY10
Gene Name		prostaglandin I2 (prostacyclin) receptor (IP)	adenylate cyclase 10 (soluble)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Axon Dendrite Growth Cone Neuronal Cell Body Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Manganese Ion Binding ATPase Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Blood Coagulation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation	CAMP Biosynthetic Process Spermatogenesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostacyclin signalling through prostacyclin receptor Signaling by GPCR G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Prostanoid ligand receptors GPCR downstream signaling Platelet homeostasis Eicosanoid ligand-binding receptors	Hedgehog 'off' state Signaling by Hedgehog
Drugs		Treprostinil Iloprost Dinoprost Tromethamine Epoprostenol
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	2 interactors: PTGIR SSTR5
Entrez ID		5739	55811
HPRD ID		08959	05549
Ensembl ID		ENSG00000160013	ENSG00000143199
Uniprot IDs		P43119	Q96PN6
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Body Fluid Levels Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Water Transport Fluid Transport Wound Healing Regulation Of Cyclase Activity Cell Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway Response To Wounding Regulation Of Melanocyte Differentiation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger CAMP Biosynthetic Process Regulation Of Developmental Pigmentation Negative Regulation Of Lyase Activity G-protein Coupled Receptor Signaling Pathway Skeletal System Development Renal Water Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Protein Transport Positive Regulation Of Adenylate Cyclase Activity CAMP Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Nucleotide Metabolic Process Cyclic Purine Nucleotide Metabolic Process Regulation Of Catalytic Activity Signal Transduction Positive Regulation Of Lyase Activity Positive Regulation Of Myeloid Leukocyte Differentiation Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Protein Localization Cyclic Nucleotide Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Signaling Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Water Homeostasis Positive Regulation Of CAMP Biosynthetic Process Chemical Homeostasis Cell Communication Developmental Pigmentation Positive Regulation Of CAMP Metabolic Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Somatostatin Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipid Cell-cell Signaling Cellular Response To Estradiol Stimulus Regulation Of CAMP-mediated Signaling Cellular Response To Estrogen Stimulus G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytokinesis Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Proliferation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Regulation Of Cytokinesis Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Response To Estradiol Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Division Response To Organic Substance Hormone-mediated Signaling Pathway Response To Glucocorticoid Response To Corticosteroid Cellular Response To Steroid Hormone Stimulus Regulation Of Insulin Secretion Regulation Of Signaling Glucose Homeostasis Cell Surface Receptor Signaling Pathway Response To Estrogen Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Regulation Of Cell Division Regulation Of Hormone Secretion
Tagcloud ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Difference) ?		accepted acei bdkrb2 cessation combinations converting cough cpn1 digenic epistatic haplotypes hypertensive kinins mme modify monogenic peptidases polymorphisms prostaglandin prostaglandins ptger3 ptgis rs11209716 rs2016848 rs4344 rs8012552 substance unresolved xpnpep1
Tagcloud (Intersection) ?