NHERF4 and ABCC2

Number of citations: 0 (PubMedID 12615054)
Data Source: BioGRID (pull down), HPRD (in vitro)

		NHERF4	ABCC2
Name		NHERF family PDZ scaffold protein 4	ATP binding cassette subfamily C member 2
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Negative Regulation Of Gene Expression Bile Acid And Bile Salt Transport Bilirubin Transport Heme Catabolic Process Xenobiotic Export From Cell Carboxylic Acid Transport Transmembrane Transport Transepithelial Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier Xenobiotic Transport Across Blood-brain Barrier
Pathways		Intestinal infectious diseases	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS Aspirin ADME Paracetamol ADME Atorvastatin ADME
Drugs		None	ATP Sulfinpyrazone Azvudine
Diseases		None	Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		No GWAS studies recorded	Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Colorectal cancer ( 24737748 26151821 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Serum metabolite levels ( 33031748 ) Stent thrombosis in response to clopidogrel treatment ( 32472697 )
Novel Interactors		3 novel interactors: FCER1G NLRX1 NOMO1	None recorded
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 NHERF1 NHERF4 PDZK1 RDX SHANK3 TUBB3 UBQLN1
Entrez ID		79849	1244
HPRD ID		06191	03065
Ensembl ID		ENSG00000172367	ENSG00000023839
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	Q92887
PDB IDs		2V90	8IZQ 8IZR 8JX7 8JXQ 8JXU 8JY4 8JY5 9BR2 9BUK 9C12 9C2I
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Protein-membrane Adaptor Activity Protein Localization To Membrane Intracellular Protein Localization Protein Localization To Plasma Membrane Microvillus Assembly Protein Localization To Cell Periphery Microvillus Organization Localization Within Membrane Filopodium Apical Part Of Cell Cell Periphery Apical Plasma Membrane Microvillus Membrane Regulation Of Transport Stereocilium Brush Border Membrane Regulation Of Cellular Component Size Renal Phosphate Ion Absorption Negative Regulation Of Store-operated Calcium Channel Activity Guanylate Cyclase Inhibitor Activity Brush Border Extracellular Exosome NF-kappaB P50/p65 Complex PDZ Domain Binding Microvillus Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Netrin Receptor Binding Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Guanylate Kinase-associated Protein Clustering ERAD Pathway Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex Regulation Of Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Vitamin D Biosynthetic Process Signaling Receptor Binding Cellular Localization Regulation Of Monoatomic Ion Transport Scavenger Receptor Binding Stereocilium Base