PDZD3 and ABCC2

Number of citations of the paper that reports this interaction (PMID 12615054)
15

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PDZD3	ABCC2
Gene Name		PDZ domain containing 3	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Subapical Complex Apical Part Of Cell	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity	Transport Drug Transmembrane Transport Response To Oxidative Stress Metabolic Process Response To Heat Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport
Pathways			ABC-family proteins mediated transport
Drugs			Adenosine triphosphate Sulfinpyrazone
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	10 interactors: AZIN1 CANX MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 UBQLN1
Entrez ID		79849	1244
HPRD ID		06191	03065
Ensembl ID		ENSG00000172367	ENSG00000023839
Uniprot IDs		B0YJ61 Q86UT5	Q92887
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis	Microvillus Assembly Microvillus Organization Protein Localization Renal Phosphate Ion Absorption Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Polyamine Transmembrane Transport Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Glutathione Transport Regulation Of Cytoskeleton Organization Negative Regulation Of Calcidiol 1-monooxygenase Activity Regulation Of Long Term Synaptic Depression Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Volume Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Chromosome Condensation Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Catalytic Activity Cellular Protein Localization Regulation Of Transmembrane Transporter Activity Cellular Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Ion Transport Negative Regulation Of Vitamin D Biosynthetic Process Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning Positive Regulation Of Synapse Structural Plasticity Negative Regulation Of Cytoskeleton Organization Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transport Positive Regulation Of Ion Transport Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Positive Regulation Of Long-term Neuronal Synaptic Plasticity Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Nicotine Negative Regulation Of Catalytic Activity
Tagcloud ?			24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Difference) ?			24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Intersection) ?