PDZD3 and SLCO3A1

Number of citations of the paper that reports this interaction (PMID 15553237)
5

Data Source:
HPRD (two hybrid)

		PDZD3	SLCO3A1
Gene Name		PDZ domain containing 3	solute carrier organic anion transporter family, member 3A1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Brush Border Subapical Complex Apical Part Of Cell	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity	Transporter Activity
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance CGMP-mediated Signaling Negative Regulation Of CGMP Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity	Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464) DNA methylation (variation) ( 23725790) Inattentive symptoms ( 18821565) Obesity-related traits ( 23251661) Response to iloperidone treatment (QT prolongation) ( 18521091)
Protein-Protein Interactions		17 interactors: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	3 interactors: PDZD3 SLC9A3R1 SLC9A3R2
Entrez ID		79849	28232
HPRD ID		06191	07502
Ensembl ID		ENSG00000172367	ENSG00000176463
Uniprot IDs		B0YJ61 Q86UT5	Q9UIG8
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?		Transmembrane Transport Ion Transport Ion Transmembrane Transport Sodium-independent Organic Anion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Drug Transport Monocarboxylic Acid Transport Quaternary Ammonium Group Transport Transport Cation Transmembrane Transport Drug Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Antibiotic Transport Toxin Transport Ammonium Transmembrane Transport Organic Cation Transport Cation Transport Oligopeptide Transport Ammonium Transport Response To Drug Inorganic Anion Transport Carnitine Transmembrane Transport Carnitine Transport Lipid Transport Lipid Localization Monovalent Inorganic Cation Transport Dipeptide Transport Histamine Uptake Positive Regulation Of ARF GTPase Activity Short-chain Fatty Acid Import Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Intestinal Epithelial Structure Maintenance Quorum Sensing Involved In Interaction With Host Sodium-dependent Organic Cation Transport Fatty Acid Transport Regulation Of Intestinal Epithelial Structure Maintenance Prostaglandin Transport Peptide Transport Hormone Transport Extraocular Skeletal Muscle Development Oligopeptide Transmembrane Transport Regulation Of Chloride Transport Amide Transport Iodide Transport Thyroid Hormone Transport Transepithelial Chloride Transport Cellular Chloride Ion Homeostasis	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of CGMP Biosynthetic Process Renal Phosphate Ion Absorption Negative Regulation Of Guanylate Cyclase Activity Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion CGMP-mediated Signaling Receptor Guanylyl Cyclase Signaling Pathway Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of CGMP Biosynthetic Process Negative Regulation Of Lyase Activity Regulation Of Excretion Regulation Of Sodium Ion Transmembrane Transporter Activity Cyclic-nucleotide-mediated Signaling Bile Acid And Bile Salt Transport Regulation Of CGMP Metabolic Process Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Water Transport Protein Complex Assembly Anion Homeostasis Fluid Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?			2b1 abcb1 abcc1 abcc2 abcc3 abcc4 abcc5 abcg2 antiretroviral antiretrovirals bcrp darunavir fold gp ls180 mdr1 mrp1 mrp2 mrp3 mrp4 mrp5 pharmacokinetics sanctuary saquinavir suboptimal transporters transporting
Tagcloud (Difference) ?			2b1 abcb1 abcc1 abcc2 abcc3 abcc4 abcc5 abcg2 antiretroviral antiretrovirals bcrp darunavir fold gp ls180 mdr1 mrp1 mrp2 mrp3 mrp4 mrp5 pharmacokinetics sanctuary saquinavir suboptimal transporters transporting
Tagcloud (Intersection) ?