NHERF4 and SLCO3A1

Number of citations: 0 (PubMedID 15553237)
Data Source: HPRD (two hybrid)

		NHERF4	SLCO3A1
Name		NHERF family PDZ scaffold protein 4	solute carrier organic anion transporter family member 3A1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Brush Border Membrane Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Protein Localization To Plasma Membrane	Monoatomic Ion Transport Prostaglandin Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Sodium-independent Organic Anion Transport Positive Regulation Of MAPK Cascade Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Intestinal infectious diseases	None
GWAS		No GWAS studies recorded	Acute lymphoblastic leukemia (childhood) ( 22076464 ) Adult body size ( 32376654 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Diastolic blood pressure ( 30224653 ) DNA methylation (variation) ( 23725790 ) Estimated glomerular filtration rate reduction (30%) ( 30955190 ) Gastroesophageal reflux disease ( 27485664 ) Inattentive symptoms ( 18821565 ) Neuritic plaque ( 25188341 ) Obesity-related traits ( 23251661 ) Orofacial cleft x maternal periconceptional alcohol use interaction (1df) ( 33937227 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Primary sclerosing cholangitis ( 27992413 ) Refractive error ( 32231278 ) Response to iloperidone treatment (QT prolongation) ( 18521091 ) Smoking initiation ( 24665060 )
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	7 interacting genes: AQP6 ARLN GOLM1 NHERF1 NHERF2 NHERF4 TRARG1
Entrez ID		79849	28232
HPRD ID		06191	07502
Ensembl ID		ENSG00000172367	ENSG00000176463
Uniprot IDs		B0YJ61 E9PPZ1 Q86UT5	Q9UIG8
PDB IDs		2V90	Not available
GO Terms Enriched among Interactors		Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Transmembrane Transport Monoatomic Ion Transport Apical Plasma Membrane Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Transport Across Blood-brain Barrier Xenobiotic Transport Organic Anion Transport Monocarboxylic Acid Transport Carboxylic Acid Transport Organic Acid Transport Basal Plasma Membrane Quaternary Ammonium Group Transmembrane Transporter Activity Plasma Membrane Organic Hydroxy Compound Transport Organic Cation Transmembrane Transporter Activity Basolateral Plasma Membrane Quaternary Ammonium Group Transport Xenobiotic Export From Cell Vascular Process In Circulatory System Lipid Transport Tripeptide Transmembrane Transporter Activity Tripeptide Import Across Plasma Membrane Oligopeptide Transmembrane Transporter Activity Circulatory System Process Membrane Bile Acid And Bile Salt Transport Organic Cation Transport Amino-acid Betaine Transmembrane Transporter Activity Symporter Activity Dipeptide Transmembrane Transporter Activity Peptide:proton Symporter Activity Carnitine Transmembrane Transporter Activity Dipeptide Transport Dipeptide Import Across Plasma Membrane Dipeptide Transmembrane Transport Import Across Plasma Membrane Carnitine Transport Carnitine Transmembrane Transport Bile Acid Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Import Into Cell Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Amino-acid Betaine Transport Serotonin Transport PDZ Domain Binding Oligopeptide Transmembrane Transport Oligopeptide Transport	Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Water Transport Localization Within Membrane Fluid Transport Endomembrane System Phosphatase Binding Nitrate Transmembrane Transporter Activity Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Apical Plasma Membrane Signaling Receptor Binding Apical Part Of Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Beta-catenin Binding Renal System Process Carbon Dioxide Transmembrane Transporter Activity Cytoplasmic Vesicle Membrane Carbon Dioxide Transmembrane Transport Cellular Localization Molecular Adaptor Activity Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Glucose Import In Response To Insulin Stimulus Monoatomic Anion Channel Activity Renal Water Transport Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Ammonium Channel Activity Intracellular Phosphate Ion Homeostasis Extracellular Matrix Structural Constituent Conferring Compression Resistance Perineuronal Net Ammonium Transmembrane Transport Water Channel Activity