PTGIR and PDE6D

Number of citations of the paper that reports this interaction (PubMedID 16527812)
0

Data Source:
HPRD (in vivo)

		PTGIR	PDE6D
Description		prostaglandin I2 receptor	phosphodiesterase 6D
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection
	Molecular Function	G Protein-coupled Receptor Activity Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation	Visual Perception Sensory Perception Of Light Stimulus
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 NHERF4 PDE6D PRKCA RAB11A TBXA2R	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		5739	5147
HPRD ID		08959	04056
Ensembl ID		ENSG00000160013	ENSG00000156973
Uniprot IDs		P43119	B8ZZK5 O43924 Q6IB24
PDB IDs		8X79 8X7A	1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW 7PAC 7PAD 7PAE 7Q9Q 7Q9R 7Q9S 7Q9U 7QF9 7QJK
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity G-protein Beta/gamma-subunit Complex Binding Cellular Response To PH Heterotrimeric G-protein Complex Response To PH Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Ketone Regulation Of Establishment Of Protein Localization Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Muscle System Process Response To Alcohol GTPase Activity Phototransduction, Visible Light GTP Binding G Protein-coupled Receptor Signaling Pathway Cellular Response To Acidic PH G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Detection Of Visible Light Regulation Of Protein Localization Regulation Of Insulin Secretion Entrainment Of Circadian Clock Enzyme Regulator Activity Response To Acidic PH Response To Prostaglandin E Regulation Of Muscle Contraction Regulation Of Biological Quality Nucleotide Binding Regulation Of Peptide Hormone Secretion Regulation Of System Process Positive Regulation Of Cardiac Muscle Hypertrophy Phototransduction Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Platelet Activation Regulation Of Body Fluid Levels Detection Of Light Stimulus Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Synaptic Vesicle Endosomal Processing Bicarbonate Binding Guanylate Cyclase Inhibitor Activity Plasma Membrane	GTPase Activity GTP Binding GDP Binding Nucleotide Binding Small GTPase-mediated Signal Transduction G Protein Activity Intracellular Signaling Cassette Ciliary Basal Body Intracellular Signal Transduction Mitotic Cytokinesis Midbody Rhodopsin Kinase Activity Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Centrosome Photoreceptor Connecting Cilium Hydrolase Activity Signal Transduction G Protein-coupled Receptor Kinase Activity Cellular Developmental Process Golgi Apparatus Extracellular Exosome Rap Protein Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Cilium Cell-cell Junction Organization Cytoskeleton Regulation Of Actin Cytoskeleton Organization Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process Regulation Of Modification Of Postsynaptic Structure Cellular Response To Forskolin Phagocytic Vesicle Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Response To Forskolin Trans-Golgi Network Transport Vesicle Protein Localization To Cell Periphery Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Modification Of Synaptic Structure Recycling Endosome Membrane Photoreceptor Disc Membrane Protein Kinase Binding Establishment Of Apical/basal Cell Polarity G-protein Beta/gamma-subunit Complex Binding Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Actin Filament Organization Cell Junction Assembly Establishment Or Maintenance Of Monopolar Cell Polarity
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