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ZNF655 and XPA
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
ZNF655
XPA
Description
zinc finger protein 655
XPA, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytosol
Nuclear Body
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Damage Recognition
DNA Repair
Base-excision Repair
Nucleotide-excision Repair
DNA Damage Response
Response To Oxidative Stress
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
UV Protection
Regulation Of Autophagy
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Transcription Initiation By RNA Polymerase II
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Generic Transcription Pathway
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Serum metabolite levels (
23093944
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Interacting Genes
156 interacting genes:
ACSL6
ANKRD11
AP1M1
ASB6
ASMTL
ATOSB
ATPAF2
BARD1
BORCS6
BYSL
C8orf34
C8orf74
CAPN7
CARD9
CBY2
CCDC116
CCDC179
CCDC57
CCDC74A
CCHCR1
CCNH
CDC37
CDK4
CDR2L
CEP57L1
CPNE7
CRACR2A
CWF19L2
DBF4B
DEUP1
DPF2
DUSP4
EGLN3
EIF4EBP1
EMILIN1
EVL
EXOSC5
FADS2
FAM81A
FAM81B
FAM90A1
FARS2
FBXL9P
FHL2
FKBP6
GEM
GFAP
GSTP1
GUCD1
HAPLN2
HEXIM2
HOMER3
HOOK1
HOXB5
HPCAL1
HSD3B7
HTT
HUNK
IDI1
IMP3
INTS10
INTS13
IP6K3
ITGB5
JRK
KIFC3
KRT40
KRT76
KRT85
KRT86
KRTAP4-12
KRTAP5-9
KRTAP9-8
LCE3C
LCE4A
LCE5A
LGALS14
LMO2
LNX1
MACO1
MAD2L2
MAGEA11
MAGEA2B
MBD3
MED21
MEMO1
METTL21A
MIS18A
MITD1
MPP3
MRFAP1
MRPL28
MTMR9
MTUS2
MXI1
NAA10
NDC80
NECAB2
NGB
NOTUM
NUDT21
NUDT22
NXT2
OIP5
OSTF1
OTUD4
P2RX7
PBX3
PCSK5
PFKFB1
POLR1C
PRR35
RIN3
RINT1
RRM1
RUNX1T1
SH2D4A
SIGLEC6
SLC12A4
SMARCD1
SMG9
SPANXN2
SPRED1
SPRY3
SRGAP2B
SZT2
TCEANC
TEKT4
TEX28
THAP6
TIMM10
TLK1
TNS2
TRAF2
TRAF5
TRAPPC2
TRAPPC2B
TRIM37
TRIM41
TRIM72
TRIP13
TSPYL4
TXNDC9
USHBP1
VAV1
VPS26C
VPS9D1
XPA
YPEL5
ZBTB16
ZC2HC1C
ZNF330
ZNF552
ZNF648
ZNF792
ZNF837
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
CEP164
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
Entrez ID
79027
7507
HPRD ID
11673
02045
Ensembl ID
ENSG00000197343
ENSG00000136936
Uniprot IDs
Q8N720
P23025
PDB IDs
8PK6
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
7AD8
8EBT
8EBU
8EBX
8EBY
Enriched GO Terms of Interacting Partners
?
Protein Binding
Identical Protein Binding
Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
TRAF2-GSTP1 Complex
Keratinization
Intermediate Filament
DNA Damage Response
DNA Repair
Mismatch Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleotide-excision Repair
Chromosome Organization
Nucleoplasm
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle Phase Transition
ATP-dependent DNA Damage Sensor Activity
Damaged DNA Binding
Response To UV
Single-stranded DNA Binding
Response To Stress
Negative Regulation Of Cell Cycle Phase Transition
Somatic Cell DNA Recombination
Mismatched DNA Binding
DNA Recombination
Chromosome, Telomeric Region
Nucleus
DNA Binding
Cellular Response To UV
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Double-strand Break Repair
Cellular Response To Light Stimulus
Cellular Response To Radiation
Regulation Of Cell Cycle Process
MutSalpha Complex Binding
MutLalpha Complex Binding
Somatic Diversification Of Immunoglobulins
Response To Radiation
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA Metabolic Process
Regulation Of Cell Cycle
Pyrimidine Dimer Repair
Negative Regulation Of Mitotic Cell Cycle
Signal Transduction In Response To DNA Damage
Regulation Of DNA Metabolic Process
Telomere Maintenance
UV-damage Excision Repair
Histone H2AXS139 Kinase Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle Phase Transition
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