ZNF655 and TRIM37

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF655	TRIM37
Gene Name		zinc finger protein 655	tripartite motif containing 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways		Generic Transcription Pathway	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		17 interactors: ASUN CARD9 CDK4 HTT KIFC3 KRT40 KRTAP4-12 MAGEA11 MAGEA2B MED21 MTUS2 RINT1 SPERT TRAF2 TRIM37 TRIP13 VAV1	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		79027	4591
HPRD ID		11673	05463
Ensembl ID		ENSG00000197343	ENSG00000108395
Uniprot IDs		D6W5T3 Q68DU4 Q8N720	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Protein Autoubiquitination Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Response To Stress Neural Plate Formation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Cell Death Golgi Organization Cell Aging Regulation Of Mitotic Cell Cycle Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Regulation Of Intracellular Signal Transduction Endomembrane System Organization Cell Cycle Process Immune Response-regulating Signaling Pathway Response To Inorganic Substance Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Zonula Adherens Maintenance Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Histone H2A-K119 Monoubiquitination Regulation Of Cell Cycle Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of JNK Cascade Response To Drug Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of Innate Immune Response Organelle Organization Regulation Of Metabolic Process Lactate Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Centriole Replication Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Regulation Of JNK Cascade Positive Regulation Of Cell Death Circadian Rhythm Regulation Of Cellular Process Protein Localization To Nucleus Response To Toxic Substance Negative Regulation Of Protein Sumoylation	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
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