ZNF655 and PFKFB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF655	PFKFB1
Description		zinc finger protein 655	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate
Pathways		Generic Transcription Pathway	PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs			D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Serum metabolite levels ( 23093944)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		156 interacting genes: ACSL6 ANKRD11 AP1M1 ASB6 ASMTL ATOSB ATPAF2 BARD1 BORCS6 BYSL C8orf34 C8orf74 CAPN7 CARD9 CBY2 CCDC116 CCDC179 CCDC57 CCDC74A CCHCR1 CCNH CDC37 CDK4 CDR2L CEP57L1 CPNE7 CRACR2A CWF19L2 DBF4B DEUP1 DPF2 DUSP4 EGLN3 EIF4EBP1 EMILIN1 EVL EXOSC5 FADS2 FAM81A FAM81B FAM90A1 FARS2 FBXL9P FHL2 FKBP6 GEM GFAP GSTP1 GUCD1 HAPLN2 HEXIM2 HOMER3 HOOK1 HOXB5 HPCAL1 HSD3B7 HTT HUNK IDI1 IMP3 INTS10 INTS13 IP6K3 ITGB5 JRK KIFC3 KRT40 KRT76 KRT85 KRT86 KRTAP4-12 KRTAP5-9 KRTAP9-8 LCE3C LCE4A LCE5A LGALS14 LMO2 LNX1 MACO1 MAD2L2 MAGEA11 MAGEA2B MBD3 MED21 MEMO1 METTL21A MIS18A MITD1 MPP3 MRFAP1 MRPL28 MTMR9 MTUS2 MXI1 NAA10 NDC80 NECAB2 NGB NOTUM NUDT21 NUDT22 NXT2 OIP5 OSTF1 OTUD4 P2RX7 PBX3 PCSK5 PFKFB1 POLR1C PRR35 RIN3 RINT1 RRM1 RUNX1T1 SH2D4A SIGLEC6 SLC12A4 SMARCD1 SMG9 SPANXN2 SPRED1 SPRY3 SRGAP2B SZT2 TCEANC TEKT4 TEX28 THAP6 TIMM10 TLK1 TNS2 TRAF2 TRAF5 TRAPPC2 TRAPPC2B TRIM37 TRIM41 TRIM72 TRIP13 TSPYL4 TXNDC9 USHBP1 VAV1 VPS26C VPS9D1 XPA YPEL5 ZBTB16 ZC2HC1C ZNF330 ZNF552 ZNF648 ZNF792 ZNF837	14 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		79027	5207
HPRD ID		11673	02411
Ensembl ID		ENSG00000197343	ENSG00000158571
Uniprot IDs		Q8N720	I1Z9G4 P16118
PDB IDs		8PK6	1K6M
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition TRAF2-GSTP1 Complex Keratinization Intermediate Filament	Vascular Endothelial Cell Response To Fluid Shear Stress Positive Regulation Of Mitotic Cell Cycle Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Extrinsic Component Of Membrane Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Phosphorylation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Postsynapse Peptidyl-serine Phosphorylation Response To Nerve Growth Factor Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Gluconeogenesis Positive Regulation Of Steroid Metabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Response To Fluid Shear Stress Positive Regulation Of Protein Localization Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Communication Regulation Of Cholesterol Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Hexose Biosynthetic Process Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Maturation
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