ERCC1 and SLX1A

Number of citations of the paper that reports this interaction (PMID 19595721)
86

Data Source:
BioGRID (pull down)

		ERCC1	SLX1A
Gene Name		excision repair cross-complementation group 1	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Transcription Factor TFIID Complex Cytoplasm	Slx1-Slx4 Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding TBP-class Protein Binding Protein Domain Specific Binding Structure-specific DNA Binding	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organismal Aging Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Oogenesis Embryonic Organ Development Chromosome Organization	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ERCC4 MKRN3 SLX1A TRMT2B UBL7 USHBP1 VPS37B XPA	6 interactors: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		2067	548593
HPRD ID		00533	18681
Ensembl ID		ENSG00000012061	ENSG00000132207
Uniprot IDs		P07992	Q9BQ83
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD
Enriched GO Terms of Interacting Partners?		DNA Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair DNA Repair Response To UV Double-strand Break Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening DNA Recombination DNA Metabolic Process Nucleotide-excision Repair, DNA Incision DNA Double-strand Break Processing Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Nucleic Acid Phosphodiester Bond Hydrolysis Viral Protein Processing Response To Light Stimulus Resolution Of Meiotic Recombination Intermediates UV Protection Cellular Response To Stress Regulation Of Telomere Maintenance Response To Radiation Chromosome Separation Virion Assembly TRNA Methylation Intracellular Transport Of Virus Catabolic Process DNA Catabolic Process, Exonucleolytic Transcription-coupled Nucleotide-excision Repair Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process RNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process TRNA Modification Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation Negative Regulation Of Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process	Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombination Cellular Response To DNA Damage Stimulus Nucleic Acid Phosphodiester Bond Hydrolysis DNA Catabolic Process, Endonucleolytic DNA Catabolic Process DNA Repair Cellular Response To Stress Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision DNA Metabolic Process Nucleotide-excision Repair Interstrand Cross-link Repair Aromatic Compound Catabolic Process Negative Regulation Of Telomere Maintenance UV Protection Double-strand Break Repair Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Response To Stress Cellular Macromolecule Catabolic Process Transcription-coupled Nucleotide-excision Repair Response To Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Catabolic Process Response To UV Cellular Response To Stimulus Response To Ionizing Radiation Response To Biotic Stimulus Post-embryonic Hemopoiesis DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Shortening Pyrimidine Dimer Repair By Nucleotide-excision Repair Regulation Of Organelle Organization Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Replicative Cell Aging Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Response To Abiotic Stimulus DNA Double-strand Break Processing Cellular Nitrogen Compound Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Aging
Tagcloud ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Difference) ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Intersection) ?