ERCC1 and RAD52

Number of citations of the paper that reports this interaction (PubMedID 14734547)
0

Data Source:
BioGRID (pull down)

		ERCC1	RAD52
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	RAD52 DNA repair protein
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		2067	5893
HPRD ID		00533	11855
Ensembl ID		ENSG00000012061	ENSG00000002016
Uniprot IDs		P07992	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress
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