ERCC1 and ERCC4

Number of citations of the paper that reports this interaction (PMID 8197175)
45

Data Source:
HPRD (in vitro, in vivo)

		ERCC1	ERCC4
Gene Name		excision repair cross-complementation group 1	excision repair cross-complementation group 4
Image
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Transcription Factor TFIID Complex Cytoplasm	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor TFIID Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding TBP-class Protein Binding Protein Domain Specific Binding Structure-specific DNA Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Structure-specific DNA Binding Protein N-terminus Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organismal Aging Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Oogenesis Embryonic Organ Development Chromosome Organization	Resolution Of Meiotic Recombination Intermediates Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Telomere Maintenance Via Telomere Shortening Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER	Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS			Bilirubin levels ( 22085899) Conduct disorder (symptom count) ( 20585324) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		8 interactors: ERCC4 MKRN3 SLX1A TRMT2B UBL7 USHBP1 VPS37B XPA	7 interactors: ERCC1 FANCG GTF2H1 RAD52 SLX1A SLX4 SPTAN1
Entrez ID		2067	2072
HPRD ID		00533	00594
Ensembl ID		ENSG00000012061	ENSG00000175595
Uniprot IDs		P07992	Q92889
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD	1Z00 2A1J 2AQ0 2KN7
Enriched GO Terms of Interacting Partners?		DNA Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair DNA Repair Response To UV Double-strand Break Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening DNA Recombination DNA Metabolic Process Nucleotide-excision Repair, DNA Incision DNA Double-strand Break Processing Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Nucleic Acid Phosphodiester Bond Hydrolysis Viral Protein Processing Response To Light Stimulus Resolution Of Meiotic Recombination Intermediates UV Protection Cellular Response To Stress Regulation Of Telomere Maintenance Response To Radiation Chromosome Separation Virion Assembly TRNA Methylation Intracellular Transport Of Virus Catabolic Process DNA Catabolic Process, Exonucleolytic Transcription-coupled Nucleotide-excision Repair Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process RNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process TRNA Modification Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation Negative Regulation Of Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process	DNA Repair Cellular Response To DNA Damage Stimulus DNA Catabolic Process Double-strand Break Repair DNA Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing DNA Recombination Cellular Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic DNA Double-strand Break Processing Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Exonucleolytic Cellular Macromolecule Catabolic Process Response To Stress Transcription-coupled Nucleotide-excision Repair Nucleic Acid Phosphodiester Bond Hydrolysis Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stimulus Post-embryonic Hemopoiesis Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nitrogen Compound Metabolic Process Catabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Response To Intra-S DNA Damage Checkpoint Signaling DNA Recombinase Assembly Gonad Development Nucleotide-excision Repair, DNA Incision Replicative Cell Aging Development Of Primary Sexual Characteristics Interstrand Cross-link Repair Germ Cell Development Cellular Response To Stimulus Negative Regulation Of Telomere Maintenance Sex Differentiation Pyrimidine Dimer Repair UV Protection Response To Sucrose Regulation Of Telomere Maintenance Response To Radiation Isotype Switching Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter
Tagcloud ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb	additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly ner os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Difference) ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb	additively additivity adducts african americans bonferroni bulky cancerous carolina corrected departures ds eradicate ercc2 hnc interacted jointly os platinum remove rs2607755 rs3136038 rs3136130 rs50871 suggestively uncorrected whites xpc
Tagcloud (Intersection) ?		ner