ERCC1 and TRMT2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ERCC1	TRMT2B
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	tRNA methyltransferase 2B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity TRNA (uracil(54)-C5)-methyltransferase Activity, S-adenosyl Methionine-dependent RRNA (uridine-C5-)-methyltransferase Activity
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	RRNA Processing RNA Processing TRNA Processing RRNA Methylation Methylation
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	3 interacting genes: AKT1 ERCC1 PTPN11
Entrez ID		2067	79979
HPRD ID		00533	06520
Ensembl ID		ENSG00000012061	ENSG00000188917
Uniprot IDs		P07992	Q96GJ1
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening	Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport T Cell Costimulation Negative Regulation Of Lipid Transport Response To Epidermal Growth Factor Regulation Of D-glucose Import Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of D-glucose Transmembrane Transport Enzyme-linked Receptor Protein Signaling Pathway Multicellular Organism Growth Developmental Process Involved In Reproduction Positive Regulation Of Mitotic Cell Cycle Ameboidal-type Cell Migration Cell Development Regulation Of TRNA Methylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Lipid Transport Response To UV Negative Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Carbohydrate Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Germ Cell Development Glucose Homeostasis Negative Regulation Of Cell-cell Adhesion Response To Insulin-like Growth Factor Stimulus Reproductive Process Mammalian Oogenesis Stage Negative Regulation Of Protein Localization TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Telomeric DNA-containing Double Minutes Formation Hemopoiesis Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Reproductive Structure Development Intestinal Epithelial Cell Migration Cerebellar Cortex Formation Animal Organ Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding
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