ERCC1 and USP45

Number of citations of the paper that reports this interaction (PubMedID 30258100)
32

Data Source:
BioGRID (two hybrid)

		ERCC1	USP45
Description		ERCC excision repair 1, endonuclease non-catalytic subunit	ubiquitin specific peptidase 45
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Neural Retina Development DNA Repair Proteolysis Cell Migration Protein Deubiquitination Photoreceptor Cell Maintenance Global Genome Nucleotide-excision Repair
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	Formation of Incision Complex in GG-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)	Erectile dysfunction ( 30297428) Pursuit maintenance gain ( 29064472)
Interacting Genes		19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	8 interacting genes: BMPR1B ERCC1 MYC SMAD1 SMURF1 SPDL1 TGFBR1 UBC
Entrez ID		2067	85015
HPRD ID		00533	11667
Ensembl ID		ENSG00000012061	ENSG00000123552
Uniprot IDs		P07992	D6RBV3 Q70EL2
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening	I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cartilage Development BMP Signaling Pathway Ubiquitin Protein Ligase Binding Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cartilage Development Positive Regulation Of Developmental Process Regulation Of Chromosome Organization Negative Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Regulation Of Cellular Component Organization Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Osteoblast Differentiation Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Cellular Developmental Process Positive Regulation Of DNA-templated Transcription Regulation Of Chondrocyte Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Bone Development Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Positive Regulation Of MiRNA Transcription Positive Regulation Of Cell Projection Organization Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Engulfment Of Target By Autophagosome Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Chromosome Organization Regulation Of Apoptotic Signaling Pathway Pattern Specification Process
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