ERCC1 and MKRN3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ERCC1	MKRN3
Gene Name		excision repair cross-complementation group 1	makorin ring finger protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Transcription Factor TFIID Complex Cytoplasm	Ribonucleoprotein Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding TBP-class Protein Binding Protein Domain Specific Binding Structure-specific DNA Binding	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Replicative Cell Aging DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organismal Aging Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Oogenesis Embryonic Organ Development Chromosome Organization	Protein Ubiquitination
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ERCC4 MKRN3 SLX1A TRMT2B UBL7 USHBP1 VPS37B XPA	55 interactors: ANKRD11 BEX2 CRACR2A ENKD1 ERCC1 FAM110A FAM124B FARS2 KIF1A LRSAM1 MDM2 MDM4 MEOX2 MNAT1 MRPS6 NABP1 NDE1 PEX10 PEX5 PRPF31 PSMA1 RBM41 RNF166 RNF32 RNF7 SCNM1 SF1 SFN TCEA2 TCHP TFAP2A TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TTC25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W
Entrez ID		2067	7681
HPRD ID		00533	04836
Ensembl ID		ENSG00000012061	ENSG00000179455
Uniprot IDs		P07992	Q13064
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD
Enriched GO Terms of Interacting Partners?		DNA Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair DNA Repair Response To UV Double-strand Break Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Incision, 3'-to Lesion DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Shortening DNA Recombination DNA Metabolic Process Nucleotide-excision Repair, DNA Incision DNA Double-strand Break Processing Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Nucleic Acid Phosphodiester Bond Hydrolysis Viral Protein Processing Response To Light Stimulus Resolution Of Meiotic Recombination Intermediates UV Protection Cellular Response To Stress Regulation Of Telomere Maintenance Response To Radiation Chromosome Separation Virion Assembly TRNA Methylation Intracellular Transport Of Virus Catabolic Process DNA Catabolic Process, Exonucleolytic Transcription-coupled Nucleotide-excision Repair Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process RNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process TRNA Modification Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation Negative Regulation Of Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Cellular Response To Stress Catabolic Process Cellular Response To DNA Damage Stimulus Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Ubiquitin-protein Transferase Activity Activation Of Innate Immune Response Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Cellular Response To Hypoxia Positive Regulation Of Innate Immune Response Cellular Response To Decreased Oxygen Levels DNA Repair Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Cycle Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Protein Ubiquitination Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Viral Process
Tagcloud ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Difference) ?		3b aa8 adp antiapoptotic became carrying cho concordance confer delay determinant ercc3 erk2 excision g5 hamster mtt ner ovary pair parental phosphatidylinositol pi player repair ribose uv24 withdrawal xpb
Tagcloud (Intersection) ?