LAT and CREB3

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		LAT	CREB3
Description		linker for activation of T cells	cAMP responsive element binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Membrane TCR Signalosome Membrane Raft	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Molecular Condensate Scaffold Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding CCR1 Chemokine Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Inflammatory Response Immune Response Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Membrane Raft Distribution Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Regulation Of Cell Growth DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Chemotaxis Response To Unfolded Protein Release From Viral Latency Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Induction Of Positive Chemotaxis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Deacetylase Activity Integrated Stress Response Signaling Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	CREB3 factors activate genes CREB3 factors activate genes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		96 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FAM209A FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35H1 SLC51B SLC61A1 SLC71A2 SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	205 interacting genes: ABHD16A ACKR2 ACSF2 ACSL5 ADTRP AGER AGPAT3 ALG3 ALG8 APH1A APOA2 APOD APPBP2 AQP1 AQP2 AQP4 AQP5 ATF3 ATF4 ATP6AP2 ATP6V0C BCAP29 BCAT2 BCL2L1 BIK BNIP2 BNIP3 BTN2A2 C2 C3orf52 CACFD1 CCR1 CD207 CD82 CDS2 CEBPG CELA3A CES1 CFHR5 CGRRF1 CHMP7 CLCN7 CLDN19 CLDND2 CLP1 CMTM5 CNPY3 CREB3L1 CREB3L3 CT45A5 CTSW CYB561 CYB5B CYBC1 CYBRD1 CYP4F2 DDIT3 DNAJC30 DOLK DRAM1 EBP EMC6 EMD ERG28 FA2H FAM3A FAM3C FDFT1 FDPS FIS1 FMO1 FMO3 FXYD3 FXYD6 GJA1 GJB2 GYPA HCFC1 HDAC3 HMOX1 HVCN1 ICAM4 IGFBP5 ITM2B JUN KCNK1 KLHL30-AS1 KRTCAP2 LAT LHFPL5 LILRB5 LMBR1L LMNA LPCAT2 LTA MAL2 MALL MARCHF5 MFSD11 MGST2 MRPL57 MS4A1 MYADM NAA10 NDUFB6 NEU1 NFE2L2 NFE2L3 NFIL3 NKG7 NRG4 ORMDL1 OS9 P4HA2 PLLP PLN PLP1 PLPP1 PLTP PMP22 PNLIPRP1 PSENEN PTCH1 PTDSS1 PTPN9 RAB23 RABAC1 RHEB RIMS3 RPRM RPS3A RRAS2 RUSF1 SACM1L SAR1B SCAMP4 SCAMP5 SCLY SCP2 SEC22B SEC61G SELENOK SERINC1 SFT2D2 SFTPC SFXN3 SHMT2 SLC19A3 SLC29A1 SLC29A2 SLC29A3 SLC2A3 SLC2A4 SLC30A2 SLC35H1 SLC38A1 SLC39A13 SLC41A2 SLC41A3 SLC49A3 SLC50A1 SLC61A1 SLC7A9 SPOCK3 SQLE ST6GAL2 STARD3 STX7 STX8 SYNGR1 SYNPR TAP1 TECR TIMM17B TIMM23B TM4SF4 TMEM100 TMEM115 TMEM140 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM222 TMEM230 TMEM234 TMEM243 TMEM51 TMEM54 TRAM1 TRAM1L1 TSPAN2 TSPAN4 TSPAN7 TTLL5 UBE2J1 UNC50 USE1 VKORC1 VTI1B YIPF2 ZDHHC11 ZDHHC21 ZDHHC9
Entrez ID		27040	10488
HPRD ID		03832	07339
Ensembl ID		ENSG00000213658	ENSG00000107175
Uniprot IDs		O43561	O43889
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Cell-cell Junction Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Binding Signal Transduction Fc-gamma Receptor Signaling Pathway Cell Activation T Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Immune Effector Process B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Differentiation T Cell Differentiation Positive Regulation Of Immune Effector Process Membrane Raft T Cell Receptor Complex Neurotrophin TRKA Receptor Binding Gamma-delta T Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Mediated Cytotoxicity Regulation Of Transport Lymphocyte Mediated Immunity T Cell Costimulation Adaptive Immune Response Leukocyte Differentiation Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Transport Mononuclear Cell Differentiation	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Transmembrane Transport Chemical Homeostasis Small Molecule Biosynthetic Process Endomembrane System Lipid Biosynthetic Process Homeostatic Process Uracil Transmembrane Transport Pyrimidine Nucleobase Transmembrane Transport Uracil Transmembrane Transporter Activity Lipid Metabolic Process Golgi Apparatus Golgi Membrane Structural Constituent Of Myelin Sheath Response To Endoplasmic Reticulum Stress Integrated Stress Response Signaling Cytidine Transport Guanine Transport Adenosine Transport Cytidine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Inosine Transport Guanine Transmembrane Transport Intracellular Chemical Homeostasis Plasma Membrane Steroid Biosynthetic Process Apical Plasma Membrane Cellular Homeostasis Sterol Biosynthetic Process Lysosomal Membrane Pyrimidine-containing Compound Transmembrane Transport Small Molecule Metabolic Process Pyrimidine Nucleoside Transport Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Uridine Transmembrane Transport Water Channel Activity Nucleoside Transport Nucleoside Transmembrane Transport Pyrimidine Nucleobase Transport Membrane Organization Regulation Of Lipid Transport Transmembrane Transporter Activity Purine Nucleobase Transmembrane Transport Chloride Channel Inhibitor Activity Protein Palmitoylation Organophosphate Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?