LAT and ZHX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LAT	ZHX2
Description		linker for activation of T cells	zinc fingers and homeoboxes 2
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Membrane TCR Signalosome Membrane Raft	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Molecular Condensate Scaffold Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Inflammatory Response Immune Response Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Membrane Raft Distribution Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Nervous System Development Central Nervous System Neuron Differentiation Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Retinal Bipolar Neuron Differentiation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Appendicular lean mass ( 33097823) Carotid intima media thickness ( 21909108 30510157) Chin dimples ( 27182965) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		96 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FAM209A FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35H1 SLC51B SLC61A1 SLC71A2 SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	9 interacting genes: APP ATXN1 DHRS2 LAT NAGPA NFYA YWHAQ ZHX1 ZHX3
Entrez ID		27040	22882
HPRD ID		03832	16458
Ensembl ID		ENSG00000213658	ENSG00000178764
Uniprot IDs		O43561	Q9Y6X8
PDB IDs			2DMP 3NAU
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Cell-cell Junction Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Binding Signal Transduction Fc-gamma Receptor Signaling Pathway Cell Activation T Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Immune Effector Process B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Differentiation T Cell Differentiation Positive Regulation Of Immune Effector Process Membrane Raft T Cell Receptor Complex Neurotrophin TRKA Receptor Binding Gamma-delta T Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Mediated Cytotoxicity Regulation Of Transport Lymphocyte Mediated Immunity T Cell Costimulation Adaptive Immune Response Leukocyte Differentiation Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Transport Mononuclear Cell Differentiation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Adult Locomotory Behavior Negative Regulation Of RNA Biosynthetic Process Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Visual Learning Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Localization Protein Heterodimerization Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Localization In Cell Protein Localization To Lysosome Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Establishment Of Protein Localization To Vacuole Protein Targeting Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Protein Targeting To Lysosome Protein Targeting To Vacuole Synaptic Vesicle Recycling Via Endosome TCR Signalosome N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Associative Learning Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Localization To Vacuole Lipophagy Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding
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