LAT and CD4

Number of citations of the paper that reports this interaction (PMID 10562325)
26

Data Source:
HPRD (in vivo)

		LAT	CD4
Gene Name		linker for activation of T cells	CD4 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Glycoprotein Binding Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Enzyme Binding Protein Kinase Binding MHC Class II Protein Binding Protein Homodimerization Activity
	Biological Process	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Cytokine Production Induction By Virus Of Host Cell-cell Fusion Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Differentiation Entry Into Host Cell T Cell Costimulation Maintenance Of Protein Location In Cell T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Protein Palmitoleylation Positive Regulation Of Protein Kinase Activity Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System	Vpu mediated degradation of CD4 Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Early Phase of HIV Life Cycle HIV Life Cycle TCR signaling Alpha-defensins PD-1 signaling Defensins Phosphorylation of CD3 and TCR zeta chains Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	38 interactors: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCH4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		27040	920
HPRD ID		03832	01740
Ensembl ID		ENSG00000213658	ENSG00000010610
Uniprot IDs		B7WPI0 G5E9K3 O43561	B0AZV7 B4DT49 P01730
PDB IDs			1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4JM2
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation	Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of T Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Signaling Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Lymphocyte Activation Leukocyte Aggregation Cellular Response To Stimulus Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Programmed Cell Death Response To Stress Leukocyte Migration Leukocyte Activation Cell Death Death Cell Activation Defense Response Homeostatic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Locomotion Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Cellular Chemical Homeostasis
Tagcloud ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	allergen asthmatics box caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tata tightly
Tagcloud (Difference) ?		abolish acting amp beginning besides contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution true unexplored usf	allergen asthmatics caat cd18 chemotactic coactivator complexity concert consists dyad exons ga gabp gabpalpha harbor inducible introns lymphocytes mast motifs posttranslational pro processed remote share supplementing symmetry tightly
Tagcloud (Intersection) ?		box tata