LAT and MAP4K1

Number of citations of the paper that reports this interaction (PMID 11279207)
5

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		LAT	MAP4K1
Gene Name		linker for activation of T cells	mitogen-activated protein kinase kinase kinase kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Cytoplasm Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Activation Of MAPKKK Activity Protein Phosphorylation Response To Stress Activation Of JUN Kinase Activity Cell Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation
Pathways		TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)
Protein-Protein Interactions		28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	20 interactors: ABL1 BLNK CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		27040	11184
HPRD ID		03832	03583
Ensembl ID		ENSG00000213658	ENSG00000104814
Uniprot IDs		B7WPI0 G5E9K3 O43561	Q92918
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation	Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Immune System Process Regulation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of MAPK Cascade Regulation Of Immune Response Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Activation Immune Response Positive Regulation Of Protein Phosphorylation Defense Response Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Kinase Activity Platelet Activation Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process MAPK Cascade Cell Surface Receptor Signaling Pathway
Tagcloud ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Difference) ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste
Tagcloud (Intersection) ?