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LAT and CD3G
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
LAT
CD3G
Description
linker for activation of T cells
CD3 gamma subunit of T-cell receptor complex
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Membrane
TCR Signalosome
Membrane Raft
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Alpha-beta T Cell Receptor Complex
Gamma-delta T Cell Receptor Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Molecular Condensate Scaffold Activity
Transmembrane Signaling Receptor Activity
Protein Binding
Signaling Receptor Complex Adaptor Activity
T Cell Receptor Binding
Identical Protein Binding
Biological Process
Adaptive Immune Response
Lymphocyte Homeostasis
Immune System Process
Inflammatory Response
Immune Response
Signal Transduction
Integrin-mediated Signaling Pathway
Ras Protein Signal Transduction
Gene Expression
Calcium-mediated Signaling
Membrane Raft Distribution
Intracellular Signal Transduction
T Cell Activation
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Protein Kinase Activity
Homeostasis Of Number Of Cells
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Adaptive Immune Response
Immune System Process
Establishment Or Maintenance Of Cell Polarity
Cell Surface Receptor Signaling Pathway
Protein Transport
T Cell Activation
Positive Thymic T Cell Selection
Gamma-delta T Cell Activation
Alpha-beta T Cell Activation
T Cell Receptor Signaling Pathway
Protein-containing Complex Assembly
Regulation Of Lymphocyte Apoptotic Process
Pathways
GPVI-mediated activation cascade
Generation of second messenger molecules
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Co-inhibition by PD-1
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Drugs
Muromonab
Teclistamab
Odronextamab
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29679657
)
Crohn's disease (
21102463
)
Educational attainment (
25201988
)
Interacting Genes
96 interacting genes:
APH1A
ASGR2
BCL2L13
BSCL2
CAMLG
CBL
CD244
CD3G
CD4
CD53
CD8A
CDIP1
CLDN2
CLDN5
CLDN7
CREB3
CXorf66
CYBC1
EGFR
FAM209A
FCGR1A
FCGR2A
FFAR2
FFAR3
FKBP7
FYN
GAB2
GJA8
GJB1
GJB3
GOLM1
GPR101
GPR151
GPR152
GPR42
GRAP
GRAP2
GRB2
ITK
JSRP1
KASH5
KCTD17
KIR2DL3
LCK
LCP2
LEUTX
LHFPL1
LHFPL5
LMNA
MAP1LC3C
MAP4K1
MEOX2
MFF
MRPS18B
MS4A7
MTIF3
NDUFAF2
OPRM1
PIK3R1
PLCG1
PLCG2
PRR4
PSCA
PTPN1
PTPN6
PTPRJ
SAR1A
SERINC2
SGTA
SGTB
SH3BP2
SHB
SLA
SLC14A2
SLC16A2
SLC18A1
SLC19A3
SLC26A6
SLC35H1
SLC51B
SLC61A1
SLC71A2
SLPI
SSMEM1
SYK
SYT2
THAP4
TM4SF18
TMEM237
TMEM45B
TMEM80
TNFRSF10D
VAV1
ZAP70
ZDHHC7
ZHX2
14 interacting genes:
CATSPERH
CD3D
CD3E
EMP1
KTN1
LAT
MAL
PMP22
TMEM19
TMEM203
TMEM54
TRA
TRB
TRD
Entrez ID
27040
917
HPRD ID
03832
07037
Ensembl ID
ENSG00000213658
ENSG00000160654
Uniprot IDs
O43561
B0YIY5
P09693
PDB IDs
1SY6
6JXR
7FJD
7FJE
7FJF
7PHR
7Q5U
8ES7
8ES8
8ES9
8JC0
8JCB
8TW4
8TW6
8WXE
8WY0
8WYI
8YC0
9BBC
9C3E
9CI8
9CIA
9CQ4
Enriched GO Terms of Interacting Partners
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Phosphotyrosine Residue Binding
Membrane
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Plasma Membrane
Immune Response-activating Signaling Pathway
Cell-cell Junction
Activation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Immune Response
Positive Regulation Of Immune Response
Fc Receptor Signaling Pathway
Lymphocyte Activation
Leukocyte Activation
Immune System Process
Regulation Of Immune System Process
Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Binding
Signal Transduction
Fc-gamma Receptor Signaling Pathway
Cell Activation
T Cell Activation
Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Immune Effector Process
B Cell Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Differentiation
T Cell Differentiation
Positive Regulation Of Immune Effector Process
Membrane Raft
T Cell Receptor Complex
Neurotrophin TRKA Receptor Binding
Gamma-delta T Cell Activation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Leukocyte Mediated Cytotoxicity
Regulation Of Transport
Lymphocyte Mediated Immunity
T Cell Costimulation
Adaptive Immune Response
Leukocyte Differentiation
Peptidyl-tyrosine Phosphorylation
Fc-epsilon Receptor Signaling Pathway
Identical Protein Binding
Positive Regulation Of Transport
Mononuclear Cell Differentiation
Alpha-beta T Cell Receptor Complex
T Cell Receptor Complex
Detection Of Tumor Cell
T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Adaptive Immune Response
Membrane Raft Distribution
Immune Response To Tumor Cell
Membrane Raft Localization
Membrane
Bleb Assembly
Positive Thymic T Cell Selection
Positive T Cell Selection
T Cell Receptor Signaling Pathway
T Cell Mediated Cytotoxicity
Thymic T Cell Selection
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
T Cell Selection
Membrane Raft Organization
Detection Of Biotic Stimulus
Signaling Receptor Complex Adaptor Activity
T Cell Mediated Immunity
Immunological Synapse
Protein Insertion Into Plasma Membrane
Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Complex
Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production
TCR Signalosome
Leukocyte Mediated Cytotoxicity
T Cell Activation
Gamma-delta T Cell Receptor Complex
Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go
Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Orbitofrontal Cortex Development
Negative Regulation Of Dopamine Receptor Signaling Pathway
Membrane Raft Polarization
Immune Response
Immune Response-activating Signaling Pathway
Alpha-beta T Cell Activation
T Cell Anergy
Negative Regulation Of Circadian Sleep/wake Cycle, Sleep
Positive Regulation Of Renal Sodium Excretion
Negative Regulation Of Dopamine Secretion
Protein Localization To Paranode Region Of Axon
Myelination
Axon Ensheathment
Compact Myelin
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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