LAT and ZDHHC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LAT	ZDHHC7
Description		linker for activation of T cells	zDHHC palmitoyltransferase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Membrane TCR Signalosome Membrane Raft	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Molecular Condensate Scaffold Activity	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Inflammatory Response Immune Response Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Membrane Raft Distribution Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Protein Targeting To Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of D-glucose Transmembrane Transport Peptidyl-L-cysteine S-palmitoylation Protein Palmitoylation Androgen Receptor Signaling Pathway Polarized Epithelial Cell Differentiation Steroid Hormone Receptor Signaling Pathway Glucose Import In Response To Insulin Stimulus Progesterone Receptor Signaling Pathway Protein Localization To Plasma Membrane Regulation Of Protein Localization To Cell-cell Junction Regulation Of Fas Signaling Pathway Regulation Of Protein Localization To Plasma Membrane D-glucose Transmembrane Transport
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Height ( 18391951 25282103) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		96 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FAM209A FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35H1 SLC51B SLC61A1 SLC71A2 SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	5 interacting genes: APP CYB561 LAT PBX2 YIPF1
Entrez ID		27040	55625
HPRD ID		03832	15722
Ensembl ID		ENSG00000213658	ENSG00000153786
Uniprot IDs		O43561	Q9NXF8
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Cell-cell Junction Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Binding Signal Transduction Fc-gamma Receptor Signaling Pathway Cell Activation T Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Immune Effector Process B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Differentiation T Cell Differentiation Positive Regulation Of Immune Effector Process Membrane Raft T Cell Receptor Complex Neurotrophin TRKA Receptor Binding Gamma-delta T Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Mediated Cytotoxicity Regulation Of Transport Lymphocyte Mediated Immunity T Cell Costimulation Adaptive Immune Response Leukocyte Differentiation Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Transport Mononuclear Cell Differentiation	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Immune Response Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Defense Response Positive Regulation Of Type II Interferon Production Defense Response To Bacterium Lipoprotein Particle Myeloid Leukocyte Activation Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Vesicle-mediated Transport Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription By RNA Polymerase II Ascorbate Homeostasis B Cell Differentiation Dendritic Cell Differentiation Plasmacytoid Dendritic Cell Differentiation Lymphocyte Activation MAML1-RBP-Jkappa- ICN1 Complex Positive Regulation Of Ephrin Receptor Signaling Pathway Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Arterial Endothelial Cell Fate Commitment Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis TCR Signalosome Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response
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