LAT and PTPRJ

Number of citations of the paper that reports this interaction (PMID 11259588)
22

Data Source:
HPRD (in vitro)

		LAT	PTPRJ
Gene Name		linker for activation of T cells	protein tyrosine phosphatase, receptor type, J
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Cell Junction Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Vasculogenesis Heart Development Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Negative Regulation Of Receptor Activity
Pathways		TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	Acute lymphoblastic leukemia (childhood) ( 22076464) D-dimer levels ( 21502573) Height ( 23563607)
Protein-Protein Interactions		28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	11 interactors: CTNNB1 CTNND1 EGFR IL2RG JUP LAT MET NOP2 PDGFRB PLCG1 SDCBP
Entrez ID		27040	5795
HPRD ID		03832	02955
Ensembl ID		ENSG00000213658	ENSG00000149177
Uniprot IDs		B7WPI0 G5E9K3 O43561	Q12913 Q9NPR5
PDB IDs			2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of MAPK Cascade Regulation Of Signal Transduction Locomotion Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Movement Of Cell Or Subcellular Component Cellular Response To Indole-3-methanol Single Organismal Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To External Stimulus Chemotaxis Signaling Fc Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Cell Communication Adherens Junction Organization Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Component Movement Immune Response Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorylation Calcium-mediated Signaling Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Estradiol Axon Guidance Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Second-messenger-mediated Signaling Metanephric Nephron Morphogenesis Regulation Of Cell Fate Specification
Tagcloud ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned
Tagcloud (Difference) ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy cebpe chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition relapsed runx1 sibs tp63 twinned
Tagcloud (Intersection) ?