LAT and FCGR2A

Number of citations of the paper that reports this interaction (PMID 10781611)
14

Data Source:
HPRD (in vivo)

		LAT	FCGR2A
Gene Name		linker for activation of T cells	Fc fragment of IgG, low affinity IIa, receptor (CD32)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	IgG Binding
	Biological Process	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response
Pathways		TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System	Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22081228) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 19915573 20228799 21297633)
Protein-Protein Interactions		28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	13 interactors: BLK CRP CRYAB FYN GP6 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1
Entrez ID		27040	2212
HPRD ID		03832	00906
Ensembl ID		ENSG00000213658	ENSG00000143226
Uniprot IDs		B7WPI0 G5E9K3 O43561	P12318
PDB IDs			1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation	Leukocyte Migration Regulation Of Immune Response Platelet Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Stress Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune System Process Wound Healing Immune System Process Positive Regulation Of Immune Response Cell Activation Response To Wounding Blood Coagulation Hemostasis Fc-epsilon Receptor Signaling Pathway Cell Migration Phagocytosis Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Autophosphorylation Locomotion Response To Peptide Hormone Cellular Response To Stimulus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Leukocyte Activation Response To Peptide Response To Hormone Movement Of Cell Or Subcellular Component Transcription Factor Import Into Nucleus Cellular Response To Hormone Stimulus
Tagcloud ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?