UPP1 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		UPP1	CRYAA
Description		uridine phosphorylase 1	crystallin alpha A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Catalytic Activity Uridine Phosphorylase Activity Thymidine Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Identical Protein Binding Deoxyuridine Phosphorylase Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Uridine Catabolic Process Pyrimidine Nucleotide Metabolic Process CMP Catabolic Process DCMP Catabolic Process Nucleoside Metabolic Process Nucleotide Catabolic Process Cellular Response To Glucose Starvation UMP Salvage UMP Catabolic Process DTMP Catabolic Process DUMP Catabolic Process Uridine Metabolic Process	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways		Pyrimidine salvage Pyrimidine catabolism
Drugs		5-Benzylacyclouridine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		3 interacting genes: CRYAA CTDP1 VIM	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		7378	1409
HPRD ID		08932	00427
Ensembl ID		ENSG00000183696	ENSG00000160202
Uniprot IDs		B4DND0 Q16831 Q86Y75	A0A8C8KJZ9 P02489
PDB IDs		3EUE 3EUF 3NBQ	6T1R
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Regulation Of Cell Growth Regulation Of Cellular Component Organization Tubulin Complex Assembly Response To UV-A Regulation Of Growth Lens Fiber Cell Morphogenesis Embryonic Eye Morphogenesis Apoptotic Process Involved In Morphogenesis Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Supramolecular Fiber Organization Lens Fiber Cell Development Astrocyte Development Keratin Filament Binding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Response To Muramyl Dipeptide Positive Regulation Of Collagen Biosynthetic Process Tat Protein Binding TFIIF-class Transcription Factor Complex Binding Host-mediated Activation Of Viral Transcription Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Spindle Midzone Exit From Mitosis Protein Refolding Host-mediated Perturbation Of Viral Transcription Apoptotic Process Involved In Development Protein-containing Complex Astrocyte Differentiation Negative Regulation Of Organ Growth Regulation Of Collagen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Host-mediated Activation Of Viral Process Negative Regulation Of Cardiac Muscle Hypertrophy Lens Development In Camera-type Eye Regulation Of Collagen Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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