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UCP2 and YWHAQ
Number of citations of the paper that reports this interaction (PMID
10785390
)
3
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro)
UCP2
YWHAQ
Gene Name
uncoupling protein 2 (mitochondrial, proton carrier)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Mitochondrial Inner Membrane
Integral Component Of Membrane
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Protein Domain Specific Binding
Protein N-terminus Binding
Biological Process
Response To Superoxide
Response To Hypoxia
Transport
Mitochondrial Transport
Female Pregnancy
Aging
Positive Regulation Of Cell Death
Proton Transport
Respiratory Electron Transport Chain
Cellular Response To Insulin Stimulus
Cellular Response To Amino Acid Starvation
Negative Regulation Of Apoptotic Process
Cellular Metabolic Process
Small Molecule Metabolic Process
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Response To Fatty Acid
Cellular Response To Glucose Stimulus
Liver Regeneration
Protein Targeting
Apoptotic Process
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The proton buffering model
Mitochondrial Uncoupling Proteins
The fatty acid cycling model
The citric acid (TCA) cycle and respiratory electron transport
Activation of BAD and translocation to mitochondria
Programmed Cell Death
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Heart rate variability traits (
22174390
)
Protein-Protein Interactions
6 interactors:
KRTAP10-3
KRTAP10-7
YWHAB
YWHAG
YWHAQ
YWHAZ
231 interactors:
AARS2
ABL1
ACSL4
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ATP5A1
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1L1
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HIST1H2BG
HIST2H4A
HNRNPA1
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
KCNK15
KCNK3
KCNK9
KIAA1429
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPC4
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSFA2
SSX2IP
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
Entrez ID
7351
10971
HPRD ID
03410
00886
Ensembl ID
ENSG00000134308
Uniprot IDs
P55851
B4DMT8
P27348
PDB IDs
2BTP
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Regulation Of Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intracellular Transport
Apoptotic Signaling Pathway
Positive Regulation Of Organelle Organization
Protein Targeting
Regulation Of Intracellular Transport
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Transport
Regulation Of Protein Localization
Membrane Organization
Intracellular Protein Transport
Regulation Of Organelle Organization
Apoptotic Process
Programmed Cell Death
Regulation Of Cellular Localization
Cell Death
Death
Positive Regulation Of Signal Transduction
Cellular Protein Localization
Protein Transport
Regulation Of Apoptotic Process
Establishment Of Protein Localization
Intracellular Transport
Regulation Of Cell Death
Intracellular Signal Transduction
Protein Localization
Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Cellular Localization
Regulation Of Signal Transduction
Regulation Of Signaling
Cellular Response To Insulin Stimulus
Golgi Reassembly
Response To Insulin
Negative Regulation Of Protein Dephosphorylation
Histamine Secretion By Mast Cell
Cellular Response To Peptide Hormone Stimulus
Establishment Of Golgi Localization
Cellular Response To Peptide
Golgi Inheritance
Histamine Secretion
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Organelle Organization
Cellular Process
Cellular Response To Organic Substance
Regulation Of Cellular Component Organization
Response To Organic Substance
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Developmental Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Metabolic Process
Response To Stress
Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle Process
Death
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Protein Localization
Intracellular Signal Transduction
Apoptotic Process
Cell Cycle Process
Anatomical Structure Development
Cell Death
Regulation Of Cellular Localization
System Development
Multicellular Organismal Development
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Abiotic Stimulus
Positive Regulation Of Protein Metabolic Process
Intracellular Transport
Regulation Of Signaling
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Regulation Of Phosphorylation
Innate Immune Response
MRNA Metabolic Process
Cellular Localization
Immune System Process
Regulation Of Kinase Activity
Tagcloud
?
1s
adipocyte
adipose
ap2
bip
carbonylation
chop
concomitant
enigmatic
equilibrium
fabp
fabp4
fatty
ffa
herein
hts01037
indirectly
lipopolysaccharide
macrophages
negated
null
palmitate
pharmacologic
r126q
ucp1
ucp3
uncouples
uncoupling
xbp
Tagcloud (Difference)
?
1s
adipocyte
adipose
ap2
bip
carbonylation
chop
concomitant
enigmatic
equilibrium
fabp
fabp4
fatty
ffa
herein
hts01037
indirectly
lipopolysaccharide
macrophages
negated
null
palmitate
pharmacologic
r126q
ucp1
ucp3
uncouples
uncoupling
xbp
Tagcloud (Intersection)
?