UCHL1 and SMN1

Number of citations of the paper that reports this interaction (PubMedID 20713032)
0

Data Source:
BioGRID (enzymatic study)

		UCHL1	SMN1
Description		ubiquitin C-terminal hydrolase L1	survival of motor neuron 1, telomeric
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Perikaryon Gemini Of Cajal Bodies
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly DNA-templated Transcription Termination MRNA Processing Nervous System Development RNA Splicing
Pathways		UCH proteinases	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs		Phenethyl Isothiocyanate	Nusinersen
Diseases		Parkinson's disease (PD)	Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28	166 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 BLOC1S6 BYSL CARHSP1 CCDC90B CENPB CHTOP COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EHHADH EIF3G EXT2 EZH2 FAM20C FAM9B FBL FGB FLAD1 FNDC11 FUBP1 FXR1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K IQUB ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAGED1 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NEURL2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR1C POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNU13 SNUPN SP110 SPANXN2 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		7345	6606
HPRD ID		01877	02646
Ensembl ID		ENSG00000154277	ENSG00000172062
Uniprot IDs		P09936 V9HW74	B4DP61 E7EQZ4 Q16637
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7	1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU 7W2P 7W30
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity	Spliceosomal SnRNP Assembly RNA Binding MRNA Metabolic Process RNA Splicing MRNA Processing RNA Splicing, Via Transesterification Reactions SMN-Sm Protein Complex RNA Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Metabolic Process U2-type Precatalytic Spliceosome Spliceosomal Complex Lsm2-8 Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process U6 SnRNP Lsm1-7-Pat1 Complex Nucleoplasm Precatalytic Spliceosome SMN Complex U4 SnRNP Catalytic Step 2 Spliceosome Telomerase Holoenzyme Complex U7 SnRNP Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Small Nuclear Ribonucleoprotein Complex Nucleus Gemini Of Cajal Bodies Methylosome U12-type Spliceosomal Complex PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex Cytosol U2 SnRNP Spliceosomal Complex Assembly Protein-containing Complex Assembly U1 SnRNP U7 SnRNA Binding U5 SnRNP Cytoplasm Cajal Body Histone Pre-mRNA DCP Binding U2-type Prespliceosome Assembly Protein-containing Complex Organization U6 SnRNA Binding Promoter-specific Chromatin Binding
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