UCHL1 and PLA2G2A

Number of citations of the paper that reports this interaction (PMID 22118674)
23

Data Source:
BioGRID (enzymatic study)

		UCHL1	PLA2G2A
Gene Name		ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	phospholipase A2, group IIA (platelets, synovial fluid)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Protein Deubiquitination Sensory Perception Of Pain Axon Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Low-density Lipoprotein Particle Remodeling Somatic Stem Cell Maintenance Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Phosphatidic Acid Metabolic Process Glycerophospholipid Biosynthetic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium
Pathways			Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs			Indomethacin Diclofenac Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid 1-Benzyl-5-Methoxy-2-Methyl-1h-Indol-3-Yl)-Acetic Acid 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Elaidoylamide 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Suramin
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		27 interactors: ADRA2A ADRA2B ADRA2C ADRB2 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PARK2 PLA2G2A RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	24 interactors: ALOX12 BAG6 CEP70 CRMP1 DCN JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		7345	5320
HPRD ID		01877	01397
Ensembl ID		ENSG00000154277	ENSG00000188257
Uniprot IDs		P09936	P14555
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9	1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I
Enriched GO Terms of Interacting Partners?		Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Receptor Transactivation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Norepinephrine Secretion Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Activation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorylation Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Phosphorylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Response To Abiotic Stimulus Negative Regulation Of Muscle Contraction Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERBB Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Response To Stimulus Positive Regulation Of Protein Metabolic Process	Protein Modification By Small Protein Removal Protein Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Catabolic Process Proteolysis Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein K48-linked Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Dermatan Sulfate Biosynthetic Process Regulation Of Phospholipase A2 Activity Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Chondroitin Sulfate Biosynthetic Process Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Protein Stability Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukotriene Metabolic Process Cellular Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Icosanoid Biosynthetic Process Negative Regulation Of Arachidonic Acid Secretion Lipoxin B4 Biosynthetic Process Leukotriene A4 Metabolic Process Cellular Response To DNA Damage Stimulus Unsaturated Fatty Acid Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Difference) ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	1p35 adenomas adenomatous alleles borderline characterised colonic disequilibrium duodenal fap genuine inherited locus modifier modify mom1 noncoding p36 phospholipase pla2s polymorphic polyposis polyps secretory silent sporadic syntenic undetected
Tagcloud (Intersection) ?