UCHL1 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		UCHL1	TINF2
Description		ubiquitin C-terminal hydrolase L1	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		UCH proteinases	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)	Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		7345	26277
HPRD ID		01877	16056
Ensembl ID		ENSG00000154277	ENSG00000092330
Uniprot IDs		P09936 V9HW74	B4DFJ1 Q9BSI4
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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