UCHL1 and NCAM1

Number of citations: 0 (PubMedID 23061666)
Data Source: BioGRID (pull down)

		UCHL1	NCAM1
Name		ubiquitin C-terminal hydrolase L1	neural cell adhesion molecule 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Golgi Membrane Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Neuron Projection Side Of Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding	Virus Receptor Activity Protein Binding
	Biological Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Epithelial To Mesenchymal Transition Cell Adhesion Symbiont Entry Into Host Cell Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		UCH proteinases	ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling
Drugs		Phenethyl Isothiocyanate	None
Diseases		Parkinson's disease (PD)	None
GWAS		Cognitive performance ( 19734545 ) Metabolite levels ( 23823483 )	Age at first sexual intercourse ( 34211149 27089180 ) Blood protein levels ( 30072576 ) Body mass index ( 25673413 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Cannabis use ( 27023175 30150663 ) Cardiac muscle measurement ( 21212386 ) Coffee consumption ( 31046077 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Depression ( 33859377 ) Entorhinal cortical thickness ( 21116278 ) Experiencing mood swings ( 29500382 ) Feeling miserable ( 29500382 ) Feeling tense ( 29500382 ) Frailty index ( 34431594 ) Gastroesophageal reflux disease ( 33608531 ) General factor of neuroticism ( 30867560 ) Gut microbiota (bacterial taxa) ( 27694959 ) Haemorrhoidal disease ( 33888516 ) Heel bone mineral density ( 30598549 28869591 ) Irritable bowel syndrome ( 33608531 ) LDL levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429 ) Macular thickness ( 30535121 ) Mood instability ( 31168069 ) Neurociticism ( 29500382 ) Number of sexual partners ( 30643258 ) Pulse pressure ( 27841878 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Sense of smell ( 26632684 ) Smoking initiation ( 33082346 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (current vs never) ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Smoking status (heavy vs never) ( 26423011 ) Suicide attempts in depression or bipolar disorder ( 24964207 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429 )
Interacting Genes		30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28	19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		7345	4684
HPRD ID		01877	00301
Ensembl ID		ENSG00000154277	ENSG00000149294
Uniprot IDs		P09936 V9HW74	A0A087WWD4 H7BYX6 P13591
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7	2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN
GO Terms Enriched among Interactors		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity	Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sialylation Enzyme-linked Receptor Protein Signaling Pathway Ganglioside Biosynthetic Process Regulation Of Synapse Organization Sialyltransferase Activity N-glycan Processing Sialic Acid Binding Ganglioside Metabolic Process Postsynapse Glycosphingolipid Biosynthetic Process Regulation Of Neuron Apoptotic Process System Development Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Neuron Projection Development Positive Regulation Of Nervous System Development Regulation Of Programmed Cell Death Cell Projection Organization Negative Regulation Of Dendritic Spine Maintenance Developmental Process Plasma Membrane Bounded Cell Projection Organization Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Extrinsic Apoptotic Signaling Pathway Ceramide Biosynthetic Process Glycosphingolipid Metabolic Process Cell Migration Oligosaccharide Metabolic Process Golgi Apparatus Positive Regulation Of Developmental Process Regulation Of Apoptotic Signaling Pathway Salivary Gland Morphogenesis Glycolipid Biosynthetic Process Dendritic Spine Maintenance Regulation Of Multicellular Organismal Process Neuron Projection Guidance Axon Guidance Regulation Of Nervous System Development Regulation Of Developmental Process Membrane Raft Cell Motility Macromolecule Biosynthetic Process Regulation Of Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Protein N-linked Glycosylation Adult Locomotory Behavior