UCHL1 and ADRA2C

Number of citations of the paper that reports this interaction (PMID 19477270)
4

Data Source:
BioGRID (pull down)

		UCHL1	ADRA2C
Gene Name		ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	adrenoceptor alpha 2C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Axon Terminus
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Protein Deubiquitination Sensory Perception Of Pain Axon Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Bethanidine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Tizanidine Apomorphine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Iloperidone Asenapine Droxidopa Xylometazoline Lurasidone Agmatine
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		27 interactors: ADRA2A ADRA2B ADRA2C ADRB2 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PARK2 PLA2G2A RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	5 interactors: EIF2B1 GNAO1 PPP1R9B UCHL1 YWHAZ
Entrez ID		7345	152
HPRD ID		01877	00085
Ensembl ID		ENSG00000154277	ENSG00000184160
Uniprot IDs		P09936	P18825 Q4W594
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9
Enriched GO Terms of Interacting Partners?		Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Receptor Transactivation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Norepinephrine Secretion Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Activation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorylation Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Phosphorylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Response To Abiotic Stimulus Negative Regulation Of Muscle Contraction Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERBB Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Response To Stimulus Positive Regulation Of Protein Metabolic Process	Response To Morphine Neurogenesis Response To Ammonium Ion Cell Development Response To Alkaloid Neuron Projection Development Response To Organonitrogen Compound Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Regulation Of Catalytic Activity Cellular Response To Morphine Neuron Development Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Locomotory Behavior Axon Transport Of Mitochondrion Neuron Differentiation Cell Projection Organization Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Translation In Response To Stress Histamine Secretion Cell Differentiation Response To Stress Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Generation Of Neurons Golgi Localization Regulation Of Translation In Response To Stress Filopodium Assembly Negative Regulation Of Translational Initiation Mast Cell Degranulation System Development Cellular Response To Ammonium Ion Response To Drug Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Stimulus Regulation Of Cellular Protein Metabolic Process Mast Cell Mediated Immunity Lysosome Localization Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Eating Behavior Mast Cell Activation
Tagcloud ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified
Tagcloud (Difference) ?		1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax	16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified
Tagcloud (Intersection) ?